Actinomycetes are a diverse family of filamentous bacteria that produce a plethora of natural
products relevant for agriculture, biotechnology and medicine, including the majority of the …

We have developed a general profile for the proteins of the TetR family of repressors. The
stretch that best defines the profile of this family is made up of 47 amino acid residues that …

During the life cycle of the filamentous bacteria Streptomyces, morphological differentiation
is closely integrated with fundamental growth and cell-cycle processes, as well as with truly …

Bacterial sigma (σ) factors are an essential component of RNA polymerase and determine
promoter selectivity. The substitution of one σ factor for another can redirect some or all of …

Streptomyces coelicolor is the genetically best characterized species of a populous genus
belonging to the gram-positive Actinobacteria. Streptomycetes are filamentous soil …

Streptomycetes are highly metabolically gifted bacteria with the abilities to produce
bioproducts that have profound economic and societal importance. These bioproducts are …

Abstract A-factor (2-isocapryloyl-3 R-hydroxymethyl-γ-butyrolactone) is a microbial hormone
that triggers aerial mycelium formation and secondary metabolism in Streptomyces griseus …

By complementing developmental mutants of Streptomyces coelicolor A3 (2), at least 15
regulatory genes for sporulation have been identified and studied at the molecular level, and …

Introduction 3. A-factor and decision point 4. A-factor receptor protein (ArpA) as a
transcriptional repressor 5. A-factor signal transfer from ArpA to streptomycin biosynthetic …

The Streptomyces produce a plethora of secondary metabolites including antibiotics and
undergo a complex developmental cycle. As a means of establishing the pathways that …