To bridge the gap between organ demand and supply, xenotransplantation has long been
considered as a realistic option for end-stage organ failure. Early this year this promise …

Pig organ xenotransplantation offers a solution to the shortage of deceased human organs
for transplantation. The pathobiological response to a pig xenograft is complex, involving …

Natural preformed and de novo antibodies against pig antigens are a major cause of pig
xenograft rejection in nonhuman primates (NHPs). In vivo studies in pig-to-NHP models are …

The human leukocyte antigen G1 (HLA-G1), a non-classical class I major histocompatibility
complex (MHC-I) protein, is a potent immunomodulatory molecule at the maternal/fetal …

Pig kidney xenotransplantation has the potential to alleviate the current shortage of
deceased and living human organs and provide patients with end‐stage renal disease with …

Half a million patients in the USA alone require treatment for burns annually. Following an
extensive burn, it may not be possible to provide sufficient autografts in a single setting …

Background Long‐term immunosuppressive maintenance therapy is necessary to prevent
the rejection of xenografts. However, it is still unclear which oral immunosuppressant is most …

目的探讨新型转录因子Musculin 对小鼠骨髓来源树突状细胞(bone marrow-derived dendritic
cells, BMDC) 生物学功能的影响. 方法获取野生型(wildtype, WT) 和Musculin 敲除(knockout …

Abstract Genome-Scale Metabolic Models (GEMMs) are powerful reconstructions of
biological systems that help metabolic engineers understand and predict growth conditions …