Transforming growth factor-β-induced protein (TGFBIp), an extracellular matrix protein, is the
second most abundant protein in the corneal stroma. In this review, we summarize the …

Inter-α-inhibitor heavy chain 4 (ITIH4) is a poorly characterized plasma protein that is
proteolytically processed in multiple pathological conditions. However, no biological function …

HTRA1 has emerged as a major risk gene for stroke and cerebral small vessel disease with
both rare and common variants contributing to disease risk. However, the precise …

Background Mass spectrometry (MS)-based cerebrospinal fluid (CSF) proteomics is an
important method for discovering biomarkers of neurodegenerative diseases. CSF serves as …

Congenital cataract is the leading cause of blindness among children worldwide. Patients
with posterior subcapsular congenital cataract (PSC) in the central visual axis can result in …

Purpose To investigate the gene mutations and relationship of clinical manifestation in a
Chinese family with familial lattice corneal dystrophy (LCD). Design Single-family case …

Corneal dystrophies are a group of genetically inherited disorders with mutations in the
TGFBI gene affecting the Bowman's membrane and the corneal stroma. The mutant TGFBIp …

TGFBI-related corneal dystrophy (CD) is characterized by the accumulation of insoluble
protein deposits in the corneal tissues, eventually leading to progressive corneal opacity …

Stromal corneal dystrophies are a group of hereditary disorders caused by mutations in the
TGFBI gene. The mutant TGFBIp is prone to protein aggregation and the mutant protein gets …

Epigenetic mechanisms, including histone acetylation, are pivotal for learning and memory,
with a role in neuronal function in Alzheimer's disease and Related Dementia (ADRD) …