Histone deacetylases (HDACs) are zinc-dependent deacetylases that remove acetyl groups
from lysine residues of histones or form protein complexes with other proteins for …

Parkinson's disease is a progressive neurodegenerative disorder, predominantly of the
motor system. Although some genetic components and cellular mechanisms of Parkinson's …

Cognitive impairment is a prevalent co-morbidity associated with epilepsy. Emerging studies
indicate that neuroinflammation could be a possible link between epilepsy and its …

Endosomal acid base balance functions as a master orchestrator within the cell, engaging
with many cellular pathways to maintain homeostasis. Mutations in the endosomal pH …

Herein, we describe the design, synthesis, and biological evaluation of 15 Contilisant+
Tubastatin A hybrids. These ligands are polyfunctionalized indole derivatives developed by …

Inspired by the intricate cellular morphology and the discoid shape of red blood cells
(RBCs), biomimetic tricompartmental microcarriers (TCM) with controlled release profiles …

An array of diverse processes and factors have been linked to the pathoetiology and
pathophysiology of Parkinson's disease (PD), including systemic CNS factors. This article …

Introduction Poweromin X Ten (PXT) is a polyherbal formulation, traditionally used to
enhance male sexual function. However, the safety and benefits of PXT have not been …

The carcinogenesis process includes several epigenetic modifications that mainly target the
silencing of tumor suppressor genes (TS genes) including ribonucleic acid (RNA) editing …