Type 2 immunity is orchestrated by a canonical group of cytokines primarily produced by
innate lymphoid cells, group 2, and their adaptive counterparts, CD4+ helper type 2 cells …

Type 2 immune responses form a critical defence against enteric worm infections. In recent
years, mouse models have revealed shared and unique functions for group 2 innate …

Cell–cell interactions in the central nervous system play important roles in neurologic
diseases. However, little is known about the specific molecular pathways involved, and …

Protective immunity relies on the interplay of innate and adaptive immune cells with
complementary and redundant functions. Innate lymphoid cells (ILCs) have recently …

Eosinophils are granulocytes that play an essential role in type 2 immunity and regulate
multiple homeostatic processes in the small intestine (SI). However, the signals that regulate …

Innate lymphoid cells (ILCs) and adaptive T lymphocytes promote tissue homeostasis and
protective immune responses. Their production depends on the transcription factor GATA3 …

The gastrointestinal tract is an immunologically rich organ, containing complex cell networks
and dense lymphoid structures that safeguard this large absorptive barrier from pathogens …

The initiation of type 2 immune responses at mucosal barriers is regulated by rapidly
secreted cytokines called alarmins. The alarmins IL-33, IL-25 and TSLP are mainly secreted …

Recent research in neuroimmunology has revolutionized our understanding of the intricate
interactions between the immune system and the central nervous system (CNS). The CNS …

Inflammation is an essential host defense mechanism in response to microbial infection and
tissue injury. In addition to its well-established role in infection, inflammation is actively …