As a preformed defense system, complement faces a delicate challenge in providing an
immediate, forceful response to pathogens even at first encounter, while sparing host cells in …

The increasing number of clinical conditions that involve a pathological contribution from the
complement system—many of which affect the kidneys—has spurred a regained interest in …

Protein adsorption is considered to be the most important factor of the interaction between
polymeric biomaterials and body fluids or tissues. Water‐mediated hydrophobic and …

Although acute or chronic inflammation is a common component of many clinical disorders,
the underlying processes can be highly distinct. In recent years, the complement system has …

With the awareness that immune-inflammatory cross-talk is at the heart of many disorders,
the desire for novel immunomodulatory strategies in the therapy of such diseases has grown …

Innate immunity is fundamental to our defense against microorganisms. Physiologically, the
intravascular innate immune system acts as a purging system that identifies and removes …

Increasing evidence indicates an integral role for the complement system in the deleterious
inflammatory reactions that occur during critical phases of the transplantation process, such …

Cytokines are potentially useful biomarkers of sepsis and other inflammatory conditions.
Many cytokines can be released by leukocytes and platelets after sampling. The sampling …

Thrombosis associated with medical devices may lead to dramatic increases in morbidity,
mortality and increased health care costs. Innovative strategies are being developed to …

A number of clinical treatment modalities involve contact between blood and biomaterials:
these include extracorporeal circuits such as hemodialysis, cardiopulmonary bypass …