Thioredoxin, thioredoxin reductase and NADPH, the thioredoxin system, is ubiquitous from
Archea to man. Thioredoxins, with a dithiol/disulfide active site (CGPC) are the major cellular …

BACKGROUND: Thioredoxin systems, involving redox active thioredoxins and thioredoxin
reductases, sustain a number of important thioredoxin-dependent pathways. These systems …

Ferroptosis is defined as cell death triggered by iron-dependent lipid peroxidation that is
preventable by antioxidant compounds such as ferrostatin-1. Endogenous suppressors of …

Ferroptosis is form of regulated nonapoptotic cell death that is involved in diverse disease
contexts. Small molecules that inhibit glutathione peroxidase 4 (GPX4), a phospholipid …

Hydrogen sulfide signaling involves persulfide formation at specific protein Cys residues.
However, overcoming current methodological challenges in persulfide detection and …

Abstract Significance: Hydrogen sulfide (H2S) has been recognized as a physiological
mediator with a variety of functions. It regulates synaptic transmission, vascular tone …

Significance: All cells must maintain a balance between oxidants and reductants, while
allowing for fluctuations in redox states triggered by signaling, altered metabolic flow, or …

The thioredoxin reductase (TrxR) isoenzymes, TrxR1 in cytosol or nucleus and TrxR2 in
mitochondria, are essential mammalian selenocysteine (Sec)-containing flavoenzymes with …

Mercury toxicity mediated by different forms of mercury is a major health problem; however,
the molecular mechanisms underlying toxicity remain elusive. We analyzed the effects of …

Arsenic trioxide (ATO) is an effective cancer therapeutic drug for acute promyelocytic
leukemia and has potential anticancer activity against a wide range of solid tumors. ATO …