Polyamines are ubiquitous positively charged amines found in all organisms. These
molecules play a crucial role in many biological functions including cell growth, gene …

Melanoma has markedly increased worldwide during the past several decades in the
Caucasian population and is responsible for 80% of skin cancer deaths. Considering that …

Glioblastomas display hierarchies with self-renewing cancer stem-like cells (CSCs). RNA
sequencing and enhancer mapping revealed regulatory programs unique to CSCs causing …

Abstract Heme oxygenase-1 (HO-1, hmox-1) catalyzes the rate-limiting step in the heme
degradation processes. Out of three by-products of HO-1 activity, biliverdin, iron ions and …

Currently, cancer and its progression to metastasis result in a large number of deaths. The
lack of new drugs, appropriate clinical trials for metastasis preventive drugs and incomplete …

Metal-based coordination compounds have been used throughout the history of human
medicine to treat various diseases, including cancer. Since the discovery of cisplatin in …

Six morpholine-(iso) thiosemicarbazone hybrids HL 1–HL 6 and their Cu (II) complexes with
good-to-moderate solubility and stability in water were synthesized and characterized. Cu …

Cancer is a disease that is a “moving target”, since as the condition progresses, the
molecular targets change and evolve. Moreover, due to clonal selection, a specific anti …

Deferoxamine (DFO) has been in use for half a century as a Food and Drug Administration-
approved iron chelator, but recent studies indicate a variety of properties that could expand …

NDRG1 is an oncogenic signaling disruptor that plays a key role in multiple cancers,
including aggressive pancreatic tumors. Recent studies have indicated a role for NDRG1 in …