BACKGROUND: Some drugs used for sedation and anesthesia produce histopathologic
central nervous system changes in juvenile animal models. These observations have raised …

γ-Aminobutyric acidA (GABAA) receptors mediate most of the fast inhibitory
neurotransmission in the CNS. They represent a major site of action for clinically relevant …

Changes to the electroencephalogram (EEG) observed during general anesthesia are
modeled with a physiological mean field theory of electrocortical activity. To this end a …

General anaesthesia has become so safe since its introduction just over 150 years ago that
the risk associated with it has become almost immeasurably small: less than one death …

Nicotinic acetylcholine receptors are pentameric proteins that belong to the Cys-loop
receptor superfamily. Their essential mechanism of functioning is to couple neurotransmitter …

General anaesthetics gain access to all parts of the body and thus interact at the molecular
level with every component in the biosphere including lipids, proteins and even …

In this final article I shall try to summarize new scientific insights resulting from and in
connection with the Sixth International Conference on Molecular and Basic Mechanisms of …

The use of general anaesthetics has facilitated great advantages in surgery within the last
150 years. General anaesthesia is composed of several components including analgesia …

What makes a general anesthetic a general anesthetic? We shall review first what general
anesthesia is all about and which drugs are being used as anesthetics. There is neither a …

GABA, acting via GABAA receptors, is well-accepted as the main inhibitory neurotransmitter
of the mature brain, where it dampens neuronal excitability. The receptor's properties have …