Functional and biomimetic materials for engineering of the three-dimensional cell microenvironment

G Huang, F Li, X Zhao, Y Ma, Y Li, M Lin, G Jin… - Chemical …, 2017 - ACS Publications
The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

Biomechanical factors in osteoarthritis

F Guilak - Best practice & research Clinical rheumatology, 2011 - Elsevier
Biomechanical factors play an important role in the health of diarthrodial joints. Altered joint
loading–associated to obesity, malalignment, trauma or joint instability–is a critical risk factor …

[HTML][HTML] 3D-printed ABS and PLA scaffolds for cartilage and nucleus pulposus tissue regeneration

DH Rosenzweig, E Carelli, T Steffen, P Jarzem… - International journal of …, 2015 - mdpi.com
Painful degeneration of soft tissues accounts for high socioeconomic costs. Tissue
engineering aims to provide biomimetics recapitulating native tissues. Biocompatible …

TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading

CJ O'conor, HA Leddy, HC Benefield… - Proceedings of the …, 2014 - National Acad Sciences
Mechanical loading of joints plays a critical role in maintaining the health and function of
articular cartilage. The mechanism (s) of chondrocyte mechanotransduction are not fully …

[HTML][HTML] Cartilage and diarthrodial joints as paradigms for hierarchical materials and structures

VC Mow, A Ratcliffe, AR Poole - Biomaterials, 1992 - Elsevier
The anatomic forms of diarthrodial joints are important structural features which provide and
limit the motions required for the joint. Typically, the length scale of topographic variation of …

[图书][B] Bone mechanics handbook

SC Cowin - 2001 - taylorfrancis.com
This second edition of the Bone Mechanics Handbook summarizes the current
understanding of bone mechanics with comprehensive coverage of the histology …

Role of extracellular matrix assembly in interstitial transport in solid tumors

PA Netti, DA Berk, MA Swartz, AJ Grodzinsky, RK Jain - Cancer research, 2000 - AACR
The extracellular matrix (ECM) may contribute to the drug resistance of a solid tumor by
preventing the penetration of therapeutic agents. We measured differences in interstitial …

[HTML][HTML] Application of alginate hydrogels for next-generation articular cartilage regeneration

W Liu, H Madry, M Cucchiarini - International Journal of Molecular …, 2022 - mdpi.com
The articular cartilage has insufficient intrinsic healing abilities, and articular cartilage
injuries often progress to osteoarthritis. Alginate-based scaffolds are attractive biomaterials …

Biodegradable polymeric scaffolds for musculoskeletal tissue engineering

CM Agrawal, RB Ray - … Research: An Official Journal of The …, 2001 - Wiley Online Library
Biodegradable scaffolds have played an important role in a number of tissue engineering
attempts over the past decade. The goal of this review article is to provide a brief overview of …

Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair

J Kisiday, M Jin, B Kurz, H Hung… - Proceedings of the …, 2002 - National Acad Sciences
Emerging medical technologies for effective and lasting repair of articular cartilage include
delivery of cells or cell-seeded scaffolds to a defect site to initiate de novo tissue …