The ATP-dependent BRG1/BRM associated factor (BAF) chromatin remodeling complexes
are crucial in regulating gene expression by controlling chromatin dynamics. Over the last …

Epigenetic mechanisms regulate cell differentiation during embryonic development and also
serve as important interfaces between genes and the environment in adulthood …

The mechanisms generating epileptic neuronal networks following insults such as severe
seizures are unknown. We have previously shown that interfering with the function of the …

Epigenetic regulation represents a fundamental mechanism to maintain cell‐type‐specific
gene expression during development and serves as an essential mediator to interface the …

Epigenetics is one of the most rapidly developing fields of biological research.
Breakthroughs in several technologies have enabled the possibility of genome-wide …

The ability to convert human somatic cells efficiently to neurons facilitates the utility of patient-
derived neurons for studying neurological disorders. As such, ectopic expression of …

The cerebral cortex comprises over three quarters of the brain, and serves as structural
basis for the sophisticated perceptual and cognitive functions. It develops from common …

Within the two neurogenic niches of the adult mammalian brain, ie, the subventricular zone
lining the lateral ventricle and the subgranular zone of the hippocampus, there exist distinct …

REST [RE1-silencing transcription factor (also called neuron-restrictive silencer factor)] is
known to repress thousands of possible target genes, many of which are neuron specific. To …

Stroke is a major public health concern. The lack of effective therapies heightens the need
for new therapeutic targets. Mammalian brain has the ability to rewire itself to restore lost …