Ischemic stroke, which accounts for 75–80% of all strokes, is the predominant cause of
morbidity and mortality worldwide. The post-stroke immune response has recently emerged …

The immune and nervous systems have unique developmental trajectories that individually
build intricate networks of cells with highly specialized functions. These two systems have …

Microglia and complement can mediate neurodegeneration in Alzheimer's disease (AD). By
integrative multi-omics analysis, here we show that astrocytic and microglial proteins are …

Traumatic brain injury (TBI) is a leading cause of morbidity and disability, with a
considerable socioeconomic burden. Heterogeneity of pathoanatomical subtypes and …

Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Cell death is prevalent throughout life; however, the coordinated interactions and roles of
phagocytes during corpse removal in the live brain are poorly understood. We developed …

Ischemic stroke can cause secondary myelin damage in the white matter distal to the
primary injury site. The contribution of astrocytes during secondary demyelination and the …

Microglia are the principal phagocytes that clear cell debris in the central nervous system
(CNS). This raises the question, which cells remove cell debris when microglial phagocytic …

Astrocytes become reactive following various brain insults; however, the functions of reactive
astrocytes are poorly understood. Here, we show that reactive astrocytes function as …

Microglia-mediated synaptic loss contributes to the development of cognitive impairments in
Alzheimer's disease (AD). However, the basis for this immune-mediated attack on synapses …