Intra-abdominal sepsis: new definitions and current clinical standards

A Hecker, M Reichert, CJ Reuß, T Schmoch… - … archives of surgery, 2019 - Springer
Purpose The abdomen is the second most common source of sepsis and is associated with
unacceptably high morbidity and mortality. Recently, the essential definitions of sepsis and …

Penetration of antibacterial agents into pulmonary epithelial lining fluid: an update

EN Drwiega, KA Rodvold - Clinical pharmacokinetics, 2022 - Springer
A comprehensive review of drug penetration into pulmonary epithelial lining fluid (ELF) was
previously published in 2011. Since then, an extensive number of studies comparing plasma …

Pharmacokinetics and dosing of ceftobiprole medocaril for the treatment of hospital-and community-acquired pneumonia in different patient populations

A Torres, JW Mouton, F Pea - Clinical Pharmacokinetics, 2016 - Springer
Hospital-acquired pneumonia (HAP) and community-acquired pneumonia (CAP) are among
the most common infections treated in the hospital setting, and together they place a …

The issue of pharmacokinetic-driven drug-drug interactions of antibiotics: a narrative review

D Cattaneo, C Gervasoni, A Corona - Antibiotics, 2022 - mdpi.com
Patients in intensive care units (ICU) are at high risk to experience potential drug-drug
interactions (pDDIs) because of the complexity of their drug regimens. Such pDDIs may be …

Acute infectious osteomyelitis in children: new treatment strategies for an old enemy

S Congedi, C Minotti, C Giaquinto, L Da Dalt… - World Journal of …, 2020 - Springer
Background Acute osteomyelitis still represents a significant clinical challenge, with an
increasing incidence in paediatric population. A careful assessment and a rapid diagnosis …

Safety and effectiveness of fifth generation cephalosporins for the treatment of methicillin-resistant staphylococcus aureus bloodstream infections: a narrative review …

DF Bavaro, A Belati, L Bussini, V Cento… - Expert Opinion on …, 2024 - Taylor & Francis
ABSTRACT Introduction Methicillin-resistant Staphylococcus aureus (MRSA) bloodstream
infection (BSI) is a major issue in healthcare, since it is often associated with endocarditis or …

[HTML][HTML] Nuevas cefalosporinas

T Olarte-Luis, D Cáceres-Galíndez… - Revista chilena de …, 2018 - SciELO Chile
La resistencia bacteriana se ha incrementado en América Latina y el mundo, por lo que se
requiere investigación y creación de nuevos antimicrobianos capaces de erradicar a los …

Pharmacokinetic and Pharmacodynamic Target Attainment in Adult and Pediatric Patients Following Administration of Ceftaroline Fosamil as a 5‐Minute Infusion

TA Riccobene, TJ Carrothers, W Knebel… - Clinical …, 2021 - Wiley Online Library
The key pharmacokinetic/pharmacodynamic (PK/PD) efficacy index for β‐lactam antibiotics
is the percentage of time that free drug concentrations exceed the minimum inhibitory …

Comprehensive Evaluation of the Metabolism of Genipin-1-β-d-gentiobioside in Vitro and in Vivo by Using HPLC-Q-TOF

P Jiang, Y Ma, Y Gao, Z Li, S Lian, Z Xu… - Journal of agricultural …, 2016 - ACS Publications
To examine the metabolism of genipin-1-β-d-gentiobioside (GG), its distribution and
biotransformation in vivo and in vitro were investigated. Urine, plasma, feces, and various …

Clinical response and hospital costs of therapeutic drug monitoring for vancomycin in elderly patients

Y Kim, S Kim, J Park, H Lee - Journal of personalized medicine, 2022 - mdpi.com
Cost-effectiveness analysis has been widely used to assess and compare the costs and
benefits of a clinical service. The cost-effectiveness of vancomycin therapeutic drug …