Thrombin is the key enzyme of the entire hemostatic process since it is able to exert both
procoagulant and anticoagulant functions; therefore, it represents an attractive target for the …

Aptamers are synthetic nucleic acids that are developed to target with high affinity and
specificity chemical entities ranging from single ions to macromolecules and present a wide …

Rationale: While thrombin is the key protease in thrombus formation, other coagulation
proteases, such as fXa (factor Xa) or aPC (activated protein C), independently modulate …

The long-range communication between the two exosites of human α-thrombin (thrombin)
tightly modulates the protein-effector interactions. Duplex/quadruplex aptamers represent an …

The success in treatment of venous thromboembolism and acute coronary syndromes using
direct thrombin inhibitors has stimulated research aimed at finding a new anticoagulant from …

Human α-thrombin (thrombin) is a multifunctional enzyme that plays a pivotal role in the
coagulation pathway. Thrombin activity can be effectively modulated by G-quadruplex …

Micromycetes are known to secrete numerous enzymes of biotechnological and medical
potential. Fibrinolytic protease-activator of protein C (PAPC) of blood plasma from …

Background At sites of vessel injury, thrombin acts as the central mediator of coagulation by
catalyzing fibrin clot formation and platelet activation. Thrombin generation is most …

Hirudin from Hirudo medicinalis is a bivalent α‐Thrombin (αT) inhibitor, targeting the enzyme
active site and exosite‐I, and is currently used in anticoagulant therapy along with its …

Background Polyphosphate (polyP) promotes feedback activation of factor (F) XI by thrombin
by serving as a template. The contribution of thrombin's exosites to these interactions is …