Chronic stress-induced emotional disorders like anxiety and depression involve imbalances
between the excitatory glutamatergic system and the inhibitory GABAergic system in the …

Traditional pharmacological treatments for depression have a delayed therapeutic onset,
ranging from several weeks to months, and there is a high percentage of individuals who …

The amygdala processes positive and negative valence and contributes to addiction, but the
cell-type-specific gene regulatory programs involved are unknown. We generated an atlas of …

Background and objective Depression is a complex neuropsychiatric disease with extensive
morbidity. Its pathogenesis remains unclear, and it is associated with extremely low rates of …

Background We hypothesized that propofol, a unique general anesthetic that engages N-
methyl-D-aspartate and gamma-aminobutyric acid receptors, has antidepressant properties …

Stress, encompassing psychological, physical, and physiological challenges, is an important
factor affecting an individual's well-being and potentially leading to psychiatric …

摘要采用慢性温和不可预期应激(Chronic unpredictable mild stress, CUMS)
模型评价人参皂苷Rg1 [10, 20, 40 mg/(kg· d), ip, 7 d] 对抑郁样行为的保护作用 …

Anxiety and depression are common, highly comorbid psychiatric diseases that account for
a large proportion of worldwide medical disability. Glyoxalase 1 (GLO1) has been identified …

Methylglyoxal (MGO) is an endogenous toxin, mainly produced as a by-product of glycolysis
that has been associated to aging, Alzheimer's disease, and inflammation. Cell culture …

Bisphenol A (BPA) exposure is associated with a plethora of neurodevelopmental
abnormalities and brain disorders. Previous studies have demonstrated BPA-induced …