Living cells are constantly exposed to mechanical stimuli arising from the surrounding
extracellular matrix (ECM) or from neighboring cells. The intracellular molecular processes …

It is well established that cells sense chemical signals from their local microenvironment and
transduce them to the nucleus to regulate gene expression programmes. Although a number …

Signals from the microenvironment around a cell are known to influence cell behavior.
Material properties, such as biochemical composition and substrate stiffness, are today …

Forces generated by the cytoskeleton can be transmitted to the nucleus and chromatin via
physical links on the nuclear envelope and the lamin meshwork. Although the role of these …

Integrin-dependent adhesions are mechanosensitive structures in which talin mediates a
linkage to actin filaments either directly or indirectly by recruiting vinculin. Here, we report …

Fibroblasts exhibit heterogeneous cell geometries in tissues and integrate both mechanical
and biochemical signals in their local microenvironment to regulate genomic programs via …

Cells in the body reside within the extracellular matrix (ECM), a three-dimensional
environment that not only provides structural support for the cells, but also influences cellular …

Cells respond to mechanical forces by activating specific genes and signaling pathways that
allow the cells to adapt to their physical environment. Examples include muscle growth in …

The nucleus is sculpted toward various morphologies during cellular differentiation and
development. Alterations in nuclear shape often result in changes to chromatin organization …

Mechanical integration of the nucleus with the extracellular matrix (ECM) is established by
linkage between the cytoskeleton and the nucleus. This integration is hypothesized to …