Design and optimization of topical methotrexate loaded niosomes for enhanced management of psoriasis: application of Box–Behnken design, in-vitro evaluation and …

AA Abdelbary, MHH AbouGhaly - International journal of pharmaceutics, 2015 - Elsevier
Psoriasis, a skin disorder characterized by impaired epidermal differentiation, is regularly
treated by systemic methotrexate (MTX), an effective cytotoxic drug but with numerous side …

Polymer‐based therapeutics: nanoassemblies and nanoparticles for management of atherosclerosis

DR Lewis, K Kamisoglu, AW York… - Wiley Interdisciplinary …, 2011 - Wiley Online Library
Coronary arterial disease, one of the leading causes of adult mortality, is triggered by
atherosclerosis. A disease with complex etiology, atherosclerosis results from the …

Amphiphilic macromolecule self-assembled monolayers suppress smooth muscle cell proliferation

JW Chan, Y Zhang, KE Uhrich - Bioconjugate Chemistry, 2015 - ACS Publications
A significant limitation of cardiovascular stents is restenosis, where excessive smooth
muscle cell (SMC) proliferation following stent implantation causes blood vessel …

Micellar and structural stability of nanoscale amphiphilic polymers: implications for anti-atherosclerotic bioactivity

Y Zhang, Q Li, WJ Welsh, PV Moghe, KE Uhrich - Biomaterials, 2016 - Elsevier
Atherosclerosis, a leading cause of mortality in developed countries, is characterized by the
buildup of oxidized low-density lipoprotein (oxLDL) within the vascular intima, unregulated …

Interfacing exogenous stents with human coronary artery by self-assembled coating: designs, functionalities and applications

F Zhao, F Liu, C Gao, G Wang, Y Zhang, F Yu… - NPG Asia …, 2024 - nature.com
Drug-eluting stents are a commonly used treatment for coronary artery disease. However,
the coatings used in drug-eluting stents have some limitations such as poor biocompatibility …

Terbinafine Hydrochloride Trans-ungual Delivery via Nanovesicular Systems: In Vitro Characterization and Ex Vivo Evaluation

NI Elsherif, RN Shamma, G Abdelbary - Aaps Pharmscitech, 2017 - Springer
Treating a nail infection like onychomycosis is challenging as the human nail plate acts as a
formidable barrier against all drug permeation. Available oral and topical treatments have …

Simulation, in vitro, and in vivo cytotoxicity assessments of methotrexate-loaded pH-responsive nanocarriers

M Barani, M Reza Hajinezhad, S Sargazi, M Zeeshan… - Polymers, 2021 - mdpi.com
In this study, pH-responsive niosomal methotrexate (MTX) modified with ergosterol was
prepared for potential anticancer application. The prepared formulation had a size of …

Systematic optimization of cationic surface engineered mucoadhesive vesicles employing Design of Experiment (DoE): a preclinical investigation

A Verma, G Sharma, A Jain, A Tiwari, S Saraf… - International journal of …, 2019 - Elsevier
Fungal keratitis (FK) is treated by topical natamycin (Nat) which is an effective antifungal
agent. However, it has numerous therapeutic limitations ie toxicity, tolerance, need of …

Athero-inflammatory nanotherapeutics: Ferulic acid-based poly (anhydride-ester) nanoparticles attenuate foam cell formation by regulating macrophage lipogenesis …

RA Chmielowski, DS Abdelhamid, JJ Faig… - Acta biomaterialia, 2017 - Elsevier
Enhanced bioactive anti-oxidant formulations are critical for treatment of inflammatory
diseases, such as atherosclerosis. A hallmark of early atherosclerosis is the uptake of …

[HTML][HTML] Pectin nanoparticles loaded with nitric oxide donor drug: A potential approach for tissue regeneration

NI Elsherif, AM Al-Mahallawi, IS Ahmed… - International Journal of …, 2024 - Elsevier
The process of wound healing and tissue regeneration involves several key mechanisms to
ensure the production of new tissues with similar cellular functions. This study investigates …