Bromelain: A review of its mechanisms, pharmacological effects and potential applications

V Kumar, B Mangla, S Javed, W Ahsan, P Kumar… - Food & function, 2023 - pubs.rsc.org
The utilization of plant-derived supplements for disease prevention and treatment has long
been recognized because of their remarkable potential. Ananas comosus, commonly known …

[HTML][HTML] Exploring the therapeutic potential of bromelain: Applications, benefits, and mechanisms

U Kansakar, V Trimarco, MV Manzi, E Cervi, P Mone… - Nutrients, 2024 - mdpi.com
Bromelain is a mixture of proteolytic enzymes primarily extracted from the fruit and stem of
the pineapple plant (Ananas comosus). It has a long history of traditional medicinal use in …

Transcriptome profiling of microRNAs reveals potential mechanisms of manual therapy alleviating neuropathic pain through microRNA-547-3p-mediated Map4k4/NF …

C Yao, J Ren, R Huang, C Tang, Y Cheng, Z Lv… - Journal of …, 2022 - Springer
Background Local neuroinflammation secondary to spinal nerve compression in lumbar disk
herniation (LDH) is a key driver contributing to neuropathic pain. Manual therapy (MT), a …

Ovotransferrin Inhibits TNF-α Induced Inflammatory Response in Gastric Epithelial Cells via MAPK and NF-κB Pathway

Y Huang, S Chen, Y Yao, N Wu, M Xu… - Journal of Agricultural …, 2023 - ACS Publications
Ovotransferrin (OVT) has been confirmed to have anti-inflammatory activity. However, its
effect and mechanism on gastric inflammation are unclear. In this study, the effect and …

Analysis of the anti-inflammatory and anti-osteoarthritic potential of Flonat fast®, a combination of Harpagophytum procumbens dc. Ex Meisn., boswellia serrata Roxb …

S Quarta, G Santarpino, MA Carluccio, N Calabriso… - Pharmaceuticals, 2022 - mdpi.com
Osteoarthritis (OA) is a joint disease characterized by inflammation of the synovium,
angiogenesis, cartilage degradation, and osteophyte formation. Harpagophytum …

Combination of enzymes and rutin to manage osteoarthritis symptoms: Lessons from a narrative review of the literature

YE Henrotin, C Michlmayr, SM Rau, AM Quirke… - Rheumatology and …, 2022 - Springer
Osteoarthritis is the most common joint disorder affecting over 300 million people worldwide.
It typically affects the knees and the hips, and is characterized by a loss in normal joint …

Flaxseed Linusorb Alleviates Collagen-Induced Rheumatoid Arthritis in Rats via Inhibiting the TLR4/NF-κb/MAPK Signal Pathway and Modulating Gut Microbiota

J Li, J Chen, X Shao, N Zhang, Y Wang… - Journal of Agricultural …, 2024 - ACS Publications
Flaxseed linusorb (FL) has gradually garnered widespread attention in recent years
because of its intriguing bioactivities like anti-inflammation, antimelanogenesis, and even …

Emerging Phytochemical Formulations for Management of Rheumatoid Arthritis: A Review

P Pimple, J Shah, P Singh - Current Drug Delivery, 2025 - benthamdirect.com
Rheumatoid arthritis (RA) is a T-cell-mediated chronic inflammatory disorder affecting 0.5-
1% of the global population. The disease with unknown etiology causes slow destruction of …

[HTML][HTML] Design and Evaluation of Bromelain-Encapsulated Alginate Beads Reinforced with Gum Arabic: Formulation, Characterization, and Stability in Simulated …

M Peanparkdee, P Janchai, T Aksornsri… - Journal of Agriculture …, 2025 - Elsevier
Hydrogel beads containing purified, crude extract and commercial bromelain preparations
were developed using encapsulation technique with two carrier agents, sodium alginate and …

[HTML][HTML] Stevioside protects primary articular chondrocytes against IL-1β-induced inflammation and catabolism by targeting integrin

J Wan, Z Zhu, Z He, H Wu, A Chen, W Zhu… - International …, 2023 - Elsevier
Osteoarthritis (OA) is a common, progressive, and chronic disorder of the joints that is
characterized by the inflammation and degradation of articular cartilage and is known to …