For nearly all eukaryotic cells, stochastic DNA double-strand breaks (DSBs) are one of the
most deleterious types of DNA lesions. DSB processing and repair can cause sequence …

Leishmaniases belong to the inglorious group of neglected tropical diseases, presenting
different degrees of manifestations severity. It is caused by the transmission of more than 20 …

Maintenance of dNTPs pools in Trypanosoma brucei is dependent on both biosynthetic and
degradation pathways that together ensure correct cellular homeostasis throughout the cell …

The genomes of all organisms are read throughout their growth and development,
generating new copies during cell division and encoding the cellular activities dictated by …

Antigenic variation by variant surface glycoprotein (VSG) coat switching in African
trypanosomes is one of the most elaborate immune evasion strategies found among …

Telomeres from different eukaryotes, including trypanosomatids, are transcribed into TERRA
noncoding RNAs, crucial in regulating chromatin deposition and telomere length. TERRA is …

Genomic replication is a critical, regulated process that ensures accurate genetic information
duplication. In eukaryotic cells, strategies have evolved to prevent conflicts between …

Trypanosomatids are protozoan parasites among which are the etiologic agents of various
infectious diseases in humans, such as Trypanosoma cruzi (causative agent of Chagas …

Trypanosoma cruzi is the etiologic agent of the most prevalent human parasitic disease in
Latin America, Chagas disease. Its genome is rich in multigenic families that code for …

Trypanosoma cruzi is the etiological agent of Chagas disease and a peculiar eukaryote with
unique biological characteristics. DNA damage can block RNA polymerase, activating …