Multipronged diagnostic and therapeutic strategies for Alzheimer's disease

M Ramesh, T Govindaraju - Chemical science, 2022 - pubs.rsc.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and a major
contributor to dementia cases worldwide. AD is clinically characterized by learning, memory …

Biomolecules-derived biomaterials

LP Datta, S Manchineella, T Govindaraju - Biomaterials, 2020 - Elsevier
Human civilization has witnessed the use of materials-derived from biomolecules of plants
and animal origin for biomedical applications since ancient era. In recent years, precision …

Cyclic dipeptides: The biological and structural landscape with special focus on the anti-cancer proline-based scaffold

J Bojarska, A Mieczkowski, ZM Ziora, M Skwarczynski… - Biomolecules, 2021 - mdpi.com
Cyclic dipeptides, also know as diketopiperazines (DKP), the simplest cyclic forms of
peptides widespread in nature, are unsurpassed in their structural and bio-functional …

Cyclic dipeptide: A privileged molecular scaffold to derive structural diversity and functional utility

C Balachandra, D Padhi, T Govindaraju - ChemMedChem, 2021 - Wiley Online Library
Cyclic dipeptides (CDPs) are the simplest form of cyclic peptides with a wide range of
applications from therapeutics to biomaterials. CDP is a versatile molecular platform …

The rational design of cell-penetrating peptides for application in delivery systems

Z Kang, G Ding, Z Meng, Q Meng - Peptides, 2019 - Elsevier
Cell penetrating peptides (CPPs) play a crucial role in the transportation of bioactive
molecules. Although CPPs have been used widely in various delivery systems, further …

Ultrashort Peptides—A Glimpse into the Structural Modifications and Their Applications as Biomaterials

R Das, B Gayakvad, SD Shinde, J Rani… - ACS Applied Bio …, 2020 - ACS Publications
Because of their commanding properties, ultrashort and short peptides are gaining
significance as viable candidates for molecular self-assembly, which is a naturally inspired …

Fluorescent cyclic peptides for cell imaging

L Mendive‐Tapia, J Wang, M Vendrell - Peptide Science, 2021 - Wiley Online Library
Fluorescent cyclic peptides are excellent chemical scaffolds to build optical agents for
molecular imaging. In addition to their favorable physicochemical properties, they can be …

Cyclic dipeptide-guided aggregation-induced emission of naphthalimide and its application for the detection of phenolic drugs

C Balachandra, T Govindaraju - The Journal of Organic Chemistry, 2019 - ACS Publications
The development of novel aggregation-induced emission-based fluorophoric systems
(AIEgens) has gained prominent importance in recent years, owing to their wide range of …

A non-B DNA binding peptidomimetic channel alters cellular functions

R Paul, D Dutta, TK Mukhopadhyay, D Müller… - Nature …, 2024 - nature.com
DNA binding transcription factors possess the ability to interact with lipid membranes to
construct ion-permeable pathways. Herein, we present a thiazole-based DNA binding …

Artificial nucleobase-directed programmable synthesis and assembly of amphiphilic nucleic acids as an all-in-one platform for cation-free siRNA delivery

C Luo, Y Xie, M He, Y Xia, Y Li, L He, J Li… - … Applied Materials & …, 2022 - ACS Publications
Efficient transport of nucleic acid therapeutics into targeted cells is the key step of genetic
modulation in disease treatment. Nowadays, delivery systems strongly rely on cationic …