Introduction Acne is a chronic, inflammatory, and immune mediated disease of
pilosebaceous unit, highly prevalent in adolescents. It involves face, trunk, and back; may …

Retinoids are a class of compounds derived from vitamin A or having structural and/or
functional similarities with vitamin A. They are classified into three generations based on …

Background Acne vulgaris commonly affects adults, adolescents, and preadolescents aged
9 years or older. Objective The objective of this study was to provide evidence-based …

Background: Acne in women is often associated with anxiety and depression, and may
persist from adolescence as well as manifest for the first time in adulthood. Genetic and …

Despite many years of clinical use of isotretinoin, a comprehensive review of evidence for
isotretinoin therapy in patients with acne is lacking. We searched MEDLINE, Embase …

The topical route is the most appropriate route for the targeted delivery of drugs to skin
tissues for the treatment of local skin diseases; however, the stratum corneum (SC), the …

Acne is one of the most common diseases worldwide and affects∼ 50 million individuals in
the United States. Oral antibiotics are the most common systemic agent prescribed for the …

Background: Isotretinoin is a synthetic retinoid, derived from vitamin A, with multiple
mechanisms of action and highly effective in the treatment of acne, despite common adverse …

Background In the present study, we aimed to develop a novel isotretinoin delivery model for
treating skin diseases, revealing its potential advantages in drug delivery and targeted …

Background As a result of concerns about hypertriglyceridemia, liver enzyme abnormalities,
and leukopenia during isotretinoin therapy for acne, patients are often monitored closely …