Cisplatin (CDDP) has been widely used as a chemotherapeutic agent for solid tumors. The
most common side effect of CDDP is nephrotoxicity, and many efforts have been made in the …

Materials and Methods Low dose of CP (1 mg/kg/day; ip) was administered daily to male
and female Wistar rats for 15 consecutive days. Serum creatinine (Cr), blood urea nitrogen …

Background. The nephroprotective effect of vitamins E and C or losartan against cisplatin
(CP)‐induced nephrotoxicity when they are accompanied by estrogen was investigated …

Cisplatin (CP) as the most important anticancer drug has limited usage due to a lot of side
effects such as nephrotoxicity. Additionally, nephrotoxicity is gender/sex‐related. There is a …

Introduction. Nephrotoxicity is one the side effect of cisplatin therapy and erythropoietin has
been candidate as a nephroprotectant agent. However, its nephroprotective effect when it is …

Gender contributes to differences in incidence and progression of chronic kidney disease
(CKD) post-cisplatin therapy. This study aims at investigating the potential effect of G1 …

Erythropoietin, as a growth factor, is essential for cell proliferation and angiogenesis.
Recombinant human erythropoietin (RHE) is widely used for treatment of anemia in patients …

Background: Cisplatin (CP) is an important antitumor drug with serious side effects such as
nephrotoxicity. Estrogens can affect CP-induced nephrotoxicity; however, the role of …

Background. Nitric oxide (NO) concentration in serum is altered by cisplatin (CP), and NO
influences CP‐induced nephrotoxicity. The effect of nephroprotectant agent …

Background: Nephrotoxicity is the major side-effect of cisplatin (CDDP), and it is reported to
be gender-related. We evaluated the effects of pomegranate flower extract (PFE) as an …