Innate immunological pathways in COVID-19 pathogenesis
SR Paludan, TH Mogensen - Science immunology, 2022 - science.org
Coronavirus disease 2019 (COVID-19) is a disease characterized by a profound
dysregulation of the innate immune system. This knowledge has emerged from the large …
dysregulation of the innate immune system. This knowledge has emerged from the large …
Damage to endothelial barriers and its contribution to long COVID
X Wu, M Xiang, H Jing, C Wang, VA Novakovic, J Shi - Angiogenesis, 2024 - Springer
The world continues to contend with COVID-19, fueled by the emergence of viral variants. At
the same time, a subset of convalescent individuals continues to experience persistent and …
the same time, a subset of convalescent individuals continues to experience persistent and …
Illuminating RNA biology through imaging
RNA processing plays a central role in accurately transmitting genetic information into
functional RNA and protein regulators. To fully appreciate the RNA life-cycle, tools to …
functional RNA and protein regulators. To fully appreciate the RNA life-cycle, tools to …
Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19
E Kawakami, N Saiki, Y Yoneyama, C Moriya… - Cell Stem Cell, 2023 - cell.com
COVID-19 is linked to endotheliopathy and coagulopathy, which can result in multi-organ
failure. The mechanisms causing endothelial damage due to severe acute respiratory …
failure. The mechanisms causing endothelial damage due to severe acute respiratory …
Comorbidities and increased mortality of COVID-19 among the elderly: A systematic review
Purpose The purpose of current review is to conduct a systematic overview of articles
published between 2019 and 2021 on the relationship of comorbidities and mortality due to …
published between 2019 and 2021 on the relationship of comorbidities and mortality due to …
Caspase-4/11 exacerbates disease severity in SARS–CoV-2 infection by promoting inflammation and immunothrombosis
MM Eltobgy, A Zani, AD Kenney… - Proceedings of the …, 2022 - National Acad Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS–CoV-2) is a worldwide health
concern, and new treatment strategies are needed. Targeting inflammatory innate immunity …
concern, and new treatment strategies are needed. Targeting inflammatory innate immunity …
Innate and adaptive immunity during SARS-CoV-2 infection: biomolecular cellular markers and mechanisms
The coronavirus 2019 (COVID-19) pandemic was caused by a positive sense single-
stranded RNA (ssRNA) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
stranded RNA (ssRNA) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
SARS-CoV-2 and the spike protein in endotheliopathy
Abstract SARS-CoV-2, the causative agent of COVID-19, primarily affects the epithelial
compartment in the upper and lower airways. There is evidence that the microvasculature in …
compartment in the upper and lower airways. There is evidence that the microvasculature in …
Inflammation and vascular remodeling in COVID-19 hearts
A wide range of cardiac symptoms have been observed in COVID-19 patients, often
significantly influencing the clinical outcome. While the pathophysiology of pulmonary …
significantly influencing the clinical outcome. While the pathophysiology of pulmonary …
Extracellular vesicles and thrombosis: update on the clinical and experimental evidence
K Zifkos, C Dubois, K Schäfer - International Journal of Molecular …, 2021 - mdpi.com
Extracellular vesicles (EVs) compose a heterogenous group of membrane-derived particles,
including exosomes, microvesicles and apoptotic bodies, which are released into the …
including exosomes, microvesicles and apoptotic bodies, which are released into the …