Melatonin: both master clock output and internal time-giver in the circadian clocks network
Daily rhythms in physiological and behavioral processes are controlled by a network of
circadian clocks, reset by inputs and delivering circadian signals to the brain and peripheral …
circadian clocks, reset by inputs and delivering circadian signals to the brain and peripheral …
The melatonergic system in mood and anxiety disorders and the role of agomelatine: implications for clinical practice
Melatonin exerts its actions through membrane MT1/MT2 melatonin receptors, which belong
to the super family of G-protein-coupled receptors consisting of the typical seven …
to the super family of G-protein-coupled receptors consisting of the typical seven …
Neurobiological functions of the period circadian clock 2 gene, Per2
Most organisms have adapted to a circadian rhythm that follows a roughly 24-hour cycle,
which is modulated by both internal (clock-related genes) and external (environment) …
which is modulated by both internal (clock-related genes) and external (environment) …
Serotonergic activation potentiates light resetting of the main circadian clock and alters clock gene expression in a diurnal rodent
The main circadian clock, localized in the suprachiasmatic nuclei (SCN) in mammals, can be
synchronized by light and non-photic factors such as serotonergic cues. In nocturnal …
synchronized by light and non-photic factors such as serotonergic cues. In nocturnal …
The hormone melatonin: Animal studies
The Melatonin (MLT), secreted rhythmically by the pineal, is an efferent hormonal signal of
the circadian clock. MLT presents overall pleitropic effects but it is the role of MLT as a …
the circadian clock. MLT presents overall pleitropic effects but it is the role of MLT as a …
New light on the serotonergic paradox in the rat circadian system
The main mammalian circadian clock, localized in the suprachiasmatic nuclei can be
synchronized not only with light, but also with serotonergic activation. Serotonergic agonists …
synchronized not only with light, but also with serotonergic activation. Serotonergic agonists …
The internal time-giver role of melatonin. A key for our health
P Pévet - Revue neurologique, 2014 - Elsevier
Daily rhythms in physiological and behavioural processes are controlled by a network of
circadian clocks. In mammals, at the top of the network is a master clock located in the …
circadian clocks. In mammals, at the top of the network is a master clock located in the …
Brief daily suckling shifts locomotor behavior and induces PER1 protein in paraventricular and supraoptic nuclei, but not in the suprachiasmatic nucleus, of rabbit does
Nursing in the rabbit is a circadian event during which mother and pups interact for a period
of< 5 min every day. Here we explored behavioral and neuronal changes in the mother by …
of< 5 min every day. Here we explored behavioral and neuronal changes in the mother by …
Endogenous clock gene expression in the suprachiasmatic nuclei of previsual newborn rabbits is entrained by nursing
I Caldelas, B Gonzalez… - Developmental …, 2009 - Wiley Online Library
The rabbit is particularly suitable for investigating the development of mammalian circadian
function. Blind at birth, the pups are only visited by the mother to be nursed once every 24 h …
function. Blind at birth, the pups are only visited by the mother to be nursed once every 24 h …
Dual Effect of PER2 C111G Polymorphism on Cognitive Functions across Progression from Subjective Cognitive Decline to Mild Cognitive Impairment
S Mazzeo, V Bessi, S Bagnoli, G Giacomucci… - Diagnostics, 2021 - mdpi.com
Background: Periodic circadian protein homolog 2 (PER2) has a role in the intracellular
signaling pathways of long-term potentiation and has implications for synaptic plasticity. We …
signaling pathways of long-term potentiation and has implications for synaptic plasticity. We …