Antiretroviral therapies efficiently block HIV-1 replication but need to be maintained for life.
Moreover, chronic inflammation is a hallmark of HIV-1 infection that persists despite …

Thirty years after the identification of HIV, a cure for HIV infection is still to be achieved.
Advances of combined antiretroviral therapy (cART) in recent years have transformed HIV …

HIV persists in long-lived infected cells that are not affected by antiretroviral treatment. These
HIV reservoirs are mainly located in CD4+ T cells, but their distribution is variable in the …

The dengue virus nonstructural protein 1 (NS1) is a secreted virulence factor that modulates
complement, activates immune cells and alters endothelial barriers. The molecular basis of …

Viruses often interfere with the DNA damage response to better replicate in their hosts. The
human immunodeficiency virus 1 (HIV-1) viral protein R (Vpr) protein has been reported to …

SAMHD1 is a triphosphohydrolase enzyme that controls the intracellular level of
deoxyribonucleoside triphosphates (dNTPs) and plays a role in innate immune sensing and …

Human immunodeficiency virus type 1 (HIV-1) establishes latency in resting memory CD4+
T cells and cells of myeloid lineage. In contrast to the T cells, cells of myeloid lineage are …

Although tumor-associated macrophages have been extensively studied in the control of
response to radiotherapy, the molecular mechanisms involved in the ionizing radiation …

Human immunodeficiency virus (HIV) is still a serious global health concern responsible for
more than 25 million deaths in last three decades. More than 34 million people are living …

Background The events in early HIV infection (EHI) are important determinants of disease
severity and progression rate to AIDS, but the mechanisms of pathogenesis in EHI have not …