Neutrophil extracellular traps in homeostasis and disease

H Wang, SJ Kim, Y Lei, S Wang, H Wang… - … and Targeted Therapy, 2024 - nature.com
Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are
renowned for their propensity to expel decondensed chromatin embedded with inflammatory …

The coming of age of neutrophil extracellular traps in thrombosis: Where are we now and where are we headed?

S Van Bruggen, K Martinod - Immunological Reviews, 2023 - Wiley Online Library
Thrombosis remains a major problem in our society, manifesting across multiple
demographic groups and with high associated morbidity and mortality. Thrombus …

Neutrophil extracellular traps mediate deep vein thrombosis: from mechanism to therapy

M Yao, J Ma, D Wu, C Fang, Z Wang, T Guo… - Frontiers in …, 2023 - frontiersin.org
Deep venous thrombosis (DVT) is a part of venous thromboembolism (VTE) that clinically
manifests as swelling and pain in the lower limbs. The most serious clinical complication of …

Neutrophil extracellular trap formation is an independent risk factor for occult cancer in patients presenting with venous thromboembolism

A Rosell, G Gautam, F Wannberg, H Ng, H Gry… - Journal of Thrombosis …, 2023 - Elsevier
Background Venous thromboembolism (VTE), particularly unprovoked VTE, is associated
with occult cancer. The optimal screening regimen remains controversial. Neutrophil …

Peptidylarginine deiminase (PAD): A promising target for chronic diseases treatment

P Mansouri, P Mansouri, E Behmard… - International Journal of …, 2024 - Elsevier
In 1958, the presence of citrulline in the structure of the proteins was discovered for the first
time. Several years later they found that Arginine converted to citrulline during a post …

Reprogramming the immunosuppressive tumor microenvironment: exploiting angiogenesis and thrombosis to enhance immunotherapy

A Shafqat, MH Omer, EN Ahmed, A Mushtaq… - Frontiers in …, 2023 - frontiersin.org
This review focuses on the immunosuppressive effects of tumor angiogenesis and
coagulation on the tumor microenvironment (TME). We summarize previous research efforts …

Platelet-based nanoparticles with stimuli-responsive for anti-tumor therapy

L Yang, K Zhang, D Zheng, Y Bai, D Yue… - International Journal …, 2023 - Taylor & Francis
In addition to hemostasis and coagulation, years of studies have proved that platelets are
involved in the whole process of tumor progression, including tumor invasion, intravasation …

[HTML][HTML] Synergistic potentiation of the anti-metastatic effect of a Ginseng-Salvia miltiorrhiza herbal pair and its biological ingredients via the suppression of CD62E …

K Lu, Y Xia, P Cheng, Y Li, L He, L Tao, Z Wei… - Journal of Advanced …, 2024 - Elsevier
Introduction The combination of the roots of ginseng and Salvia miltiorrhiza is an effective
approach for treating metastatic cancer in patients with Qi stagnation and blood stasis …

Low-dose ionizing γ-radiation elicits the extrusion of neutrophil extracellular traps

A Teijeira, S Garasa, MC Ochoa… - Clinical Cancer …, 2024 - AACR
Purpose: Patients with cancer frequently undergo radiotherapy in their clinical management
with unintended irradiation of blood vessels and copiously irrigated organs in which …

[HTML][HTML] The effects of an aggressive breast tumor on thrombosis after antithrombin downregulation in a hypercoagulable mouse model

B Ünlü, M Heestermans, EH Laghmani, JT Buijs… - Thrombosis …, 2024 - Elsevier
Background Despite improvements in therapy, breast cancer still contributes to high
mortality rates. Survival of these patients becomes progressively worse upon diagnosis with …