For more than a decade, it has been known that mammalian cells use shelterin to protect
chromosome ends. Much progress has been made on the mechanism by which shelterin …

Telomeres are highly conserved tandem nucleotide repeats that include proximal double-
stranded and distal single-stranded regions that in complex with shelterin proteins afford …

Aging is characterized by functional decline occurring alongside changes to several
hallmarks of aging. One of the hallmarks includes attrition of repeated DNA sequences …

Abstract Repressor/activator protein 1 (RAP 1) is a highly evolutionarily conserved protein
found at telomeres. Although yeast Rap1 is a key telomere capping protein preventing non …

Simple Summary The segmentation of eukaryotic genomes into discrete linear
chromosomes requires processes to solve several major biological problems, including …

In this perspective, we introduce shelterin and the mechanisms of ATM activation and NHEJ
at telomeres, before discussing the following questions: How are t-loops proposed to protect …

Abstract CST (CTC1-STN1-TEN1) is a telomere associated complex that binds ssDNA and
is required for multiple steps in telomere replication, including termination of G-strand …

The evolutionarily conserved POT 1 protein binds single‐stranded G‐rich telomeric DNA
and has been implicated in contributing to telomeric DNA maintenance and the suppression …

Proper repair of DNA damage lesions is essential to maintaining genome integrity and
preventing the development of human diseases, including cancer. Increasing evidence …

The protection of telomere protein (POT1) is a telomere‐binding protein and is an essential
component of the six‐membered shelterin complex, which is associated with the telomeres …