Biochemical and cellular properties of insulin receptor signalling
RA Haeusler, TE McGraw, D Accili - Nature reviews Molecular cell …, 2018 - nature.com
The mechanism of insulin action is a central theme in biology and medicine. In addition to
the rather rare condition of insulin deficiency caused by autoimmune destruction of …
the rather rare condition of insulin deficiency caused by autoimmune destruction of …
Is there a role for coronary artery calcium scoring for management of asymptomatic patients at risk for coronary artery disease? Clinical risk scores are not sufficient to …
Blaha et al Biomarkers Are Not Enough for Risk Stratification 399 lifetime risk—the extension
of risk forecasting further into the future (Figure 1B). Although termed lifetime risk, these …
of risk forecasting further into the future (Figure 1B). Although termed lifetime risk, these …
Genome analyses of> 200,000 individuals identify 58 loci for chronic inflammation and highlight pathways that link inflammation and complex disorders
S Ligthart, A Vaez, U Võsa, MG Stathopoulou… - The American Journal of …, 2018 - cell.com
C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is
associated with multiple complex diseases. The genetic determinants of chronic …
associated with multiple complex diseases. The genetic determinants of chronic …
[HTML][HTML] Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice
BW Parks, E Nam, E Org, E Kostem, F Norheim, ST Hui… - Cell metabolism, 2013 - cell.com
Obesity is a highly heritable disease driven by complex interactions between genetic and
environmental factors. Human genome-wide association studies (GWAS) have identified a …
environmental factors. Human genome-wide association studies (GWAS) have identified a …
Uncovering the complex genetics of human character
Abstract Human personality is 30–60% heritable according to twin and adoption studies.
Hundreds of genetic variants are expected to influence its complex development, but few …
Hundreds of genetic variants are expected to influence its complex development, but few …
Testing and controlling for horizontal pleiotropy with probabilistic Mendelian randomization in transcriptome-wide association studies
Integrating results from genome-wide association studies (GWASs) and gene expression
studies through transcriptome-wide association study (TWAS) has the potential to shed light …
studies through transcriptome-wide association study (TWAS) has the potential to shed light …
Uncovering the complex genetics of human temperament
Experimental studies of learning suggest that human temperament may depend on the
molecular mechanisms for associative conditioning, which are highly conserved in animals …
molecular mechanisms for associative conditioning, which are highly conserved in animals …
Mashhad stroke and heart atherosclerotic disorder (MASHAD) study: design, baseline characteristics and 10-year cardiovascular risk estimation
M Ghayour-Mobarhan, M Moohebati, H Esmaily… - International journal of …, 2015 - Springer
Abstract Objective The Mashhad stroke and heart atherosclerotic disorder (MASHAD) study
is a 10-year cohort study that aims to evaluate the impact of various genetic, environmental …
is a 10-year cohort study that aims to evaluate the impact of various genetic, environmental …
Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders
Implicating particular genes in the generation of complex brain and behavior phenotypes
requires multiple lines of evidence. The rarity of most high-impact genetic variants typically …
requires multiple lines of evidence. The rarity of most high-impact genetic variants typically …
Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp (a)
HA Deshmukh, HM Colhoun, T Johnson… - Journal of lipid …, 2012 - ASBMB
We carried out a genome-wide association study (GWAS) of LDL-c response to statin using
data from participants in the Collaborative Atorvastatin Diabetes Study (CARDS; n= 1,156) …
data from participants in the Collaborative Atorvastatin Diabetes Study (CARDS; n= 1,156) …