Biochemistry and molecular biology of flaviviruses
Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile,
yellow fever, and Zika viruses, are critically important human pathogens that sicken a …
yellow fever, and Zika viruses, are critically important human pathogens that sicken a …
The global ecology and epidemiology of West Nile virus
C Chancey, A Grinev, E Volkova… - BioMed research …, 2015 - Wiley Online Library
Since its initial isolation in Uganda in 1937 through the present, West Nile virus (WNV) has
become an important cause of human and animal disease worldwide. WNV, an enveloped …
become an important cause of human and animal disease worldwide. WNV, an enveloped …
N6-methyladenosine modification enables viral RNA to escape recognition by RNA sensor RIG-I
Abstract Internal N 6-methyladenosine (m6A) modification is one of the most common and
abundant modifications of RNA. However, the biological roles of viral RNA m6A remain …
abundant modifications of RNA. However, the biological roles of viral RNA m6A remain …
Conventional and unconventional mechanisms for capping viral mRNA
In the eukaryotic cell, capping of mRNA 5′ ends is an essential structural modification that
allows efficient mRNA translation, directs pre-mRNA splicing and mRNA export from the …
allows efficient mRNA translation, directs pre-mRNA splicing and mRNA export from the …
The flavivirus NS2B–NS3 protease–helicase as a target for antiviral drug development
The flavivirus NS3 protein is associated with the endoplasmic reticulum membrane via its
close interaction with the central hydrophilic region of the NS2B integral membrane protein …
close interaction with the central hydrophilic region of the NS2B integral membrane protein …
Ten years of dengue drug discovery: progress and prospects
To combat neglected diseases, the Novartis Institute of Tropical Diseases (NITD) was
founded in 2002 through private–public funding from Novartis and the Singapore Economic …
founded in 2002 through private–public funding from Novartis and the Singapore Economic …
Molecular mechanisms of coronavirus RNA capping and methylation
Y Chen, D Guo - Virologica Sinica, 2016 - Springer
The 5′-cap structures of eukaryotic mRNAs are important for RNA stability, pre-mRNA
splicing, mRNA export, and protein translation. Many viruses have evolved mechanisms for …
splicing, mRNA export, and protein translation. Many viruses have evolved mechanisms for …
Structure of the L protein of vesicular stomatitis virus from electron cryomicroscopy
The large (L) proteins of non-segmented, negative-strand RNA viruses, a group that
includes Ebola and rabies viruses, catalyze RNA-dependent RNA polymerization with viral …
includes Ebola and rabies viruses, catalyze RNA-dependent RNA polymerization with viral …
Structural proteomics of dengue virus
In this paper, we discuss recent advances in our knowledge of the dengue virus life cycle
based on new structural data of the virus and its proteins. Specifically, we focus on the …
based on new structural data of the virus and its proteins. Specifically, we focus on the …
In Vitro Reconstitution of SARS-Coronavirus mRNA Cap Methylation
M Bouvet, C Debarnot, I Imbert, B Selisko… - PLoS …, 2010 - journals.plos.org
SARS-coronavirus (SARS-CoV) genome expression depends on the synthesis of a set of
mRNAs, which presumably are capped at their 5′ end and direct the synthesis of all viral …
mRNAs, which presumably are capped at their 5′ end and direct the synthesis of all viral …