The discovery of the nitric oxide/cGMP pathway was the basis for our understanding of many
normal physiological functions and the pathophysiology of several diseases. Since the …

Cyclic guanosine monophosphate (cGMP), produced by guanylate cyclase (GC), activates
protein kinase G (PKG) and regulates cardiac remodeling. cGMP/PKG signal is activated by …

Cardiac contractility is regulated by several neural, hormonal, paracrine, and autocrine
factors. Amongst these, signaling through β-adrenergic and serotonin receptors generates …

Background Recent studies have suggested that cardiac nitrosative stress mediated by
pathological overproduction of nitric oxide (NO) via inducible NO synthase (iNOS) …

The disease criteria used by the World Health Organization (WHO) were applied to human
biological aging in order to assess whether aging can be classified as a disease. These …

Although well documented drug therapies are available for the management of ventricular
hypertrophy (VH) and heart failure (HF), most patients nonetheless experience a downhill …

Erectile dysfunction (ED) is a common disorder that affects the quality of life of many
patients. It is prevalent in more than half of males aged over 60 years. Increasing evidence …

The myocardium has an intrinsic ability to sense and respond to mechanical load in order to
adapt to physiological demands. Primary examples are the augmentation of myocardial …

Over the past decade, soluble guanylate cyclase (sGC) activators and stimulators have been
developed and studied to improve outcomes in patients with heart failure with reduced …

Introduction Cyclic nucleotides, cAMP, and cGMP, are important second messengers of
intracellular signaling and play crucial roles in cardiovascular biology and diseases. Cyclic …