Classical cadherins mediate specific adhesion at intercellular adherens junctions.
Interactions between cadherin ectodomains from apposed cells mediate cell–cell contact …

Desmosomes are intercellular junctions that tether intermediate filaments to the plasma
membrane. Desmogleins and desmocollins, members of the cadherin superfamily, mediate …

Intercellular communication is essential for proper cardiac function. Mechanical and
electrical activity need to be synchronized so that the work of individual myocytes transforms …

Crystal structures of classical cadherins have revealed two dimeric configurations. In the
first, N-terminal β-strands of EC1 domains' swap'between partner molecules. The second …

Desmosomes are intercellular junctions whose primary function is strong intercellular
adhesion, known as hyperadhesion. In the present review, we discuss how their structure …

In pemphigus vulgaris, a life-threatening autoimmune skin disease, epidermal blisters are
caused by autoantibodies primarily targeting desmosomal cadherins desmoglein 3 (DSG3) …

According to the World Health Organization, the neoplasm is one of the main reasons for
morbidity and mortality worldwide. At the same time, application of cytostatic drugs like an …

Tissue integrity is crucial for maintaining the homeostasis of living organisms. Abnormalities
that affect sites of cell-cell contact can cause a variety of debilitating disorders. The …

Failure of desmosomal adhesion with ensuing keratinocyte separation–a phenomenon
called acantholysis–can result from genetic, autoimmune or infectious proteolytic causes …

During the last six decades electron microscopy (EM) has been essential to ultra-structural
studies of the cell to understand the fundamentals of cellular morphology and processes …