Vascular areas of atherosclerotic development persist in a state of inflammation, and any
further inflammatory stimulus in the subintimal area elicits a proatherogenic response; this …

Chronic persistent inflammation plays a significant role in disease pathology of cancer,
cardiovascular disease, and metabolic syndrome (MetS). MetS is a constellation of diseases …

Directed leukocyte migration is a hallmark of inflammatory immune responses. Leukotrienes
are derived from arachidonic acid and represent a class of potent lipid mediators of …

Benfotiamine, a lipid-soluble analogue of vitamin B1, is a potent antioxidant that is used as a
food supplement for the treatment of diabetic complications. Our recent study (UC Yadav et …

Accumulation of vascular smooth muscle cells (VSMC) in response to inflammatory stimuli is
a key event in atherogenesis, which commonly occurs in sinuous vessels with turbulent …

The effects of angiotensin II (Ang II) on vascular smooth muscle cells (VSMC) are modulated
by reactive oxygen species (ROS) and also involve integrin engagement. However, the …

Leukotriene B4 (LTB4) receptor 1 (BLT1), a high‐affinity GPCR for LTB4, plays important
roles in acute and chronic inflammatory diseases. Although the LTB4‐BLT1 axis is known to …

Vascular smooth muscle cells (VSMCs) are not terminally differentiated and can change
their phenotype in response to environmental cues. Phenotype switching of VSMCs to less …

Estradiol (E2) perfusion rapidly increases the strength of fast excitatory transmission and
facilitates long-term potentiation in the hippocampus, two effects likely related to its memory …

The bacterial endotoxin lipopolysaccharide (LPS) is known to induce release of arachidonic
acid (AA) and its metabolic products, which play important roles in the inflammatory process …