Abstract Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional
serine/threonine kinases best known for its critical role in learning and memory. Recent …

The importance of Ca2+ signalling in key events of cancer cell function and tumour
progression, such as proliferation, migration, invasion and survival, has recently begun to be …

By processing and abstracting diverse omics datasets into associations between genes and
their attributes, the Harmonizome database enables researchers to explore and integrate …

Inflammation is a physiological process by which the body responds to external insults and
stress conditions, and it is characterized by the production of pro-inflammatory mediators …

Heart failure is a complex clinical syndrome involving a multitude of neurohormonal
pathways including the renin-angiotensin-aldosterone system, sympathetic nervous system …

Approximately 10% of all bone fractures do not heal, resulting in patient morbidity and
healthcare costs. However, no pharmacological treatments are currently available to …

Phosphoinositide specific phospholipase Cγ (PLCγ) activates diacylglycerol (DAG)/protein
kinase C (PKC) and inositol 1, 4, 5-trisphosphate (IP3)/Ca2+/calmodulin-dependent protein …

Background Salinomycin is a monocarboxylic polyether antibiotic and is a potential
chemotherapy drug. Our previous studies showed that salinomycin inhibited cell growth and …

Purpose: Recent studies indicate that pregnancy upregulated non-ubiquitous calmodulin
kinase (PNCK) is significantly up-regulated in breast and renal carcinomas. However, the …

Intracellular calcium signaling regulates diverse physiological and pathological processes.
In solid tumors, changes to calcium channels and effectors via mutations or changes in …