Autophagy is a catabolic process aimed at recycling cellular components and damaged
organelles in response to diverse conditions of stress, such as nutrient deprivation, viral …

Cells confront DNA damage in every cell cycle. Among the most deleterious types of DNA
damage are DNA double-strand breaks (DSBs), which can cause cell lethality if unrepaired …

Although dominant gain-of-function triplet repeat expansions in the Huntingtin (HTT) gene
are the underlying cause of Huntington disease (HD), understanding the normal functions of …

Spinal cord injury (SCI) is a medical condition that results from severe trauma to the central
nervous system; it imposes great psychological and economic burdens on affected patients …

Chaperone-mediated autophagy (CMA) is activated in response to cellular stressors to
prevent cellular proteotoxicity through selective degradation of altered proteins in …

Genomic integrity of the cell is crucial for the successful transmission of genetic information
to the offspring and its survival. Persistent DNA damage induced by endogenous and …

Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein
ligase that targets different substrates for ubiquitylation and therefore regulates a variety of …

DNA lesions, constantly produced by endogenous and exogenous sources, activate the
DNA damage response (DDR), which involves detection, signaling and repair of the …

Autophagy is an evolutionary conserved, indispensable, lysosome-mediated degradation
process, which helps in maintaining homeostasis during various cellular traumas. During …

Chromosomes are susceptible to damage during their duplication and segregation or when
exposed to genotoxic stresses. Left uncorrected, these lesions can result in genomic …