Bacteria are simple and cost effective hosts for producing recombinant proteins. However,
their physiological features may limit their use for obtaining in native form proteins of some …

The intracellular expression of antibodies in mammalian cells is a strategy to inhibit the in
vivo function of selected molecules but is limited by the unpredictable behaviour of …

Display on the yeast cell wall is well suited for engineering mammalian cell-surface and
secreted proteins (eg, antibodies, receptors, cytokines) that require endoplasmic reticulum …

By analyzing the human antibody repertoire in terms of structure, amino acid sequence
diversity and germline usage, we found that seven VH and seven VL (four Vκ and three Vλ) …

The crystal structures of a germline antibody Fab fragment and its complex with hapten have
been solved at 2.1 Å resolution. These structures are compared with the corresponding …

1999-09-16 Assigned to MORPHOSYS GESELLSCHAFT FUR PROTEINOPTIMIERUNG
MBH reassignment MORPHOSYS GESELLSCHAFT FUR PROTEINOPTIMIERUNG MBH …

US7985840B2 - Synthetic antibody phage libraries - Google Patents US7985840B2 -
Synthetic antibody phage libraries - Google Patents Synthetic antibody phage libraries …

The invention provides polypeptides comprising a variant heavy chain variable framework
domain (VFR). In some embodiments, the amino acids defining the VFR form a loop ofan …

Phage display has become an important approach for the preparation of monoclonal
antibodies from both immune and nonimmune sources. This approach allows for the rapid …

The development of a new strategy for antibody humanization is described. This strategy
incorporates key recognition sequences from the parental rodent antibody into a phage …