Wound healing potential of silver nanoparticles embedded in optimized bio-inspired hybridized chitosan soft and dry hydrogel

R Abdel-Gawad, R Osman, GAS Awad… - Carbohydrate Polymers, 2024 - Elsevier
Interactive wound dressings combining healing and antimicrobial potentials, besides
ensuring patient compliance with a recognized wound care service gained considerable …

Eudragit® L100/Polyvinyl Alcohol Nanoparticles Impregnated Mucoadhesive Films as Ocular Inserts for Controlled Delivery of Erythromycin: Development …

S Mirzaeei, S Taghe, RG Alany, A Nokhodchi - Biomedicines, 2022 - mdpi.com
The fast elimination of drugs from the cornea is one of many challenges associated with the
topical administration of conventional dosage forms. The present manuscript aimed to …

Enhancing hepatoprotective action: oxyberberine amorphous solid dispersion system targeting TLR4

T Chen, Q Li, G Ai, Z Huang, J Liu, L Zeng, Z Su… - Scientific Reports, 2024 - nature.com
Oxyberberine (OBB) is a significant natural compound, with excellent hepatoprotective
properties. However, the poor water solubility of OBB hinders its release and absorption thus …

The Impact of Hypromellose on Pharmaceutical Properties of Alginate Microparticles as Novel Drug Carriers for Posaconazole

K Kruk, M Szekalska, A Basa, K Winnicka - International Journal of …, 2023 - mdpi.com
Fungal infections are a group of diseases which are challenging to treat because of drug-
resistant fungi species, drug toxicity, and often severe patient conditions. Hence, research …

Design of colon-targeted drug delivery of dexamethasone: Formulation and in vitro characterization of solid dispersions

AZ Alkilani, S Omar, J Nasereddin, R Hamed… - Heliyon, 2024 - cell.com
Colon-targeted drug delivery continues to generate increasing attention for its prospects in
treating inflammatory bowel disease (IBD). This study aimed to develop and evaluate colon …

Scope and Application of Hot Melt Extrusion in the Development of Controlled and Sustained Release Drug Delivery Systems

P Joshi, GSNK Rao, B Chatterjee - Current Pharmaceutical …, 2024 - benthamdirect.com
Controlled-release drug delivery systems (CRDDS) are more beneficial than conventional
immediate release (IRDDS) for reduced intake, prolonged duration of action, lesser adverse …

Exploring the Ocular Absorption Pathway of Fasudil Hydrochloride towards Developing a Nanoparticulate Formulation with Improved Performance

B Osi, AA Al-Kinani, ZK Al-Qaysi, M Khoder, RG Alany - Pharmaceutics, 2024 - mdpi.com
Rho-kinase (ROCK) inhibitors represent a new category of anti-glaucoma medications.
Among them, Fasudil hydrochloride, a selective ROCK inhibitor, has demonstrated …

Prediction of co-amorphous formation using non-bonded interaction energy: Molecular dynamic simulation and experimental validation

Y Deng, W Luo, Z Zheng, G Wei, S Liu, Y Jiang… - Chemical Engineering …, 2023 - Elsevier
Co-amorphous (CA) formulation is a promising strategy to improve the solubility of poorly
water-soluble drugs, however, effective prediction of a CA system is a challenge. In this …

A novel Posaconazole oral formulation using spray dried solid dispersion technology: in-vitro and in-vivo study

K Patel, V Kevlani, S Shah - Drug Delivery and Translational Research, 2024 - Springer
SD (solid dispersion) technology is one of the well-recognized solubility enhancement
methods; but the use of versatile carriers in ASD (amorphous SD) to achieve the added …

The preparation, characterization, and application of porous core–shell composite particles produced with laboratory-scale spray dryer

Z Li, L Zhu, FC Chen, YM Guan, LH Chen… - Drug Development …, 2023 - Taylor & Francis
Objective To prepare porous core–shell composite particles (PCPs) in order to improve the
flowability and compactibility of powder materials for direct compaction (DC), as well as the …