Potential therapeutic targets of Klebsiella pneumoniae: a multi-omics review perspective

S Ali, M Alam, GM Hasan… - Briefings in functional …, 2022 - academic.oup.com
The multidrug resistance developed in many organisms due to the prolonged use of
antibiotics has been an increasing global health crisis. Klebsiella pneumoniae is a causal …

Genome-scale metabolic modeling for unraveling molecular mechanisms of high threat pathogens

M Sertbas, KO Ulgen - Frontiers in Cell and Developmental Biology, 2020 - frontiersin.org
Pathogens give rise to a wide range of diseases threatening global health and hence
drawing public health agencies' attention to establish preventative and curative solutions …

Metabolic modeling predicts unique drug targets in Borrelia burgdorferi

PJ Gwynne, KLK Stocks, ES Karozichian, A Pandit… - Msystems, 2023 - Am Soc Microbiol
ABSTRACT The Lyme disease bacterium Borrelia burgdorferi is extremely host dependent,
with a small genome and correspondingly limited metabolism. As such, it is an excellent …

Key technologies for progressing discovery of microbiome-based medicines

RB Young, VR Marcelino, M Chonwerawong… - Frontiers in …, 2021 - frontiersin.org
A growing number of experimental and computational approaches are illuminating the
“microbial dark matter” and uncovering the integral role of commensal microbes in human …

Understanding antimicrobial resistance using genome-scale metabolic modeling

T Alonso-Vásquez, M Fondi, E Perrin - Antibiotics, 2023 - mdpi.com
The urgent necessity to fight antimicrobial resistance is universally recognized. In the search
of new targets and strategies to face this global challenge, a promising approach resides in …

Novel drivers of virulence in Clostridioides difficile identified via context-specific metabolic network analysis

ML Jenior, JL Leslie, DA Powers, EM Garrett… - Msystems, 2021 - Am Soc Microbiol
The pathogen Clostridioides difficile causes toxin-mediated diarrhea and is the leading
cause of hospital-acquired infection in the United States. Due to growing antibiotic …

Unveiling the role of macranthoin G in the traditional anti-infective properties of Launaea nudicaulis

FMA Bar, E Elekhnawy, TH Aldawsari… - South African Journal of …, 2024 - Elsevier
Klebsiella pneumoniae, a highly prevalent Gram-negative bacterium, is widely known for
causing nosocomial infections, leading to various diseases including systemic infections …

Genomic and transcriptomic analysis reveal multiple strategies for the cadmium tolerance in Vibrio parahaemolyticus N10-18 isolated from aquatic animal ostrea …

P Yu, L Yang, J Wang, C Su, S Qin, C Zeng, L Chen - Foods, 2022 - mdpi.com
The waterborne Vibrio parahaemolyticus can cause acute gastroenteritis, wound infection,
and septicemia in humans. Pollution of heavy metals in aquatic environments is proposed to …

PBITV3: A robust and comprehensive tool for screening pathogenic proteomes for drug targets and prioritizing vaccine candidates

S Chakraborty, M Askari, RS Barai… - Protein …, 2024 - Wiley Online Library
Rise of life‐threatening superbugs, pandemics and epidemics warrants the need for cost‐
effective and novel pharmacological interventions. Availability of publicly available …

[HTML][HTML] Genome-scale metabolic modeling in antimicrobial pharmacology

Y Zhu, J Zhao, J Li - Engineering Microbiology, 2022 - Elsevier
The increasing antimicrobial resistance has seriously threatened human health worldwide
over the last three decades. This severe medical crisis and the dwindling antibiotic discovery …