Interest in spatial omics is on the rise, but generation of highly multiplexed images remains
challenging, due to cost, expertise, methodical constraints, and access to technology. An …

While pathological tissue analysis is typically performed on single 2-dimensional (2D)
histological reference slides, 3-dimensional (3D) reconstruction from a sequence of …

In the chapters in Part I of this textbook the author introduces the fundamental ideas of
artificial intelligence and computational intelligence. In Part II he explains key AI methods …

Registration of multiple stained images is a fundamental task in histological image analysis.
In supervised methods, obtaining ground-truth data with known correspondences is …

Deformable image registration plays a critical role in various clinical applications (eg, image
fusion, atlas creation, and tumors targeting). In radiation therapy, especially in the context of …

Breast-conserving surgery requires supportive radiotherapy to prevent cancer recurrence.
However, the task of localizing the tumor bed to be irradiated is not trivial. The automatic …

Progesterone receptor (PR) plays a vital role in diagnosing and treating breast cancer, but
PR staining is costly and time-consuming, seriously hindering its application in clinical …

Although X-ray based 3D virtual histology is an emerging tool for the analysis of biological
tissue, it falls short in terms of specificity when compared to conventional histology. Thus, the …

Background and objective The automatic registration of differently stained whole slide
images (WSIs) is crucial for improving diagnosis and prognosis by fusing complementary …

Recently virtual staining technology has greatly promoted the advancement of
histopathology. Despite the practical successes achieved the outstanding performance of …