• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

From the 1Mayo Clinic, Jacksonville, Florida, 2Yale University School of Medicine, New
Haven, Connecticut, 3Cleveland Clinic Lerner College of Medicine of Case Western …

The recommendations listed in this document are, whenever possible, evidence based. An
extensive review was conducted on literature published through March 1, 2020. Searches …

Aim This executive summary of the valvular heart disease guideline provides
recommendations for clinicians to diagnose and manage valvular heart disease as well as …

Pacemakers, implantable cardiac defibrillators, and cardiac resynchronization therapy
devices are potentially life-saving treatments for a number of cardiac conditions, but are not …

LRRC4 is a novel relatively specific gene, which displays significant down-regulation in
primary brain tumor biopsies and has the potential to suppress brain tumor growth. In this …

The recommendations listed in this document are, whenever possible, evidence based. An
extensive review was conducted on literature published through November 2012, and other …

Infective endocarditis (IE), initially described more than 350 years ago, involves infection of
the endocardial surface of the heart. The clinical manifestations of IE can involve every …

Before the 1970s, 30% to 50% of US children with IE had underlying rheumatic heart
disease. 9 Because the prevalence of rheumatic heart disease has declined in developed …

Echocardiography is one of the most powerful diagnostic and monitoring tools available to
the modern emergency/critical care practitioner. Currently, there is a lack of specific …