Prostate cancer invokes major shifts in gene transcription and metabolic signaling to
mediate alterations in nutrient acquisition and metabolic substrate selection when compared …

Improved in vitro systems for predicting drug-induced toxicity are needed in the
pharmaceutical and biotechnology industries to decrease late-stage drug attrition. One …

Patients with ALS show, in addition to the loss of motor neurons in the spinal cord,
brainstem, and cerebral cortex, an abnormal depletion of energy stores alongside …

Pulmonary arterial hypertension is an incurable disease marked by dysregulated
metabolism, both at the cellular level in the pulmonary vasculature, and at the whole-body …

Embryo implantation and development requires the endometrial stromal cells (ESCs) to
undergo decidualization. This differentiation process requires glucose utilization, and …

A novel strategy of 'all water chemistry'is reported for a concise total synthesis of the novel
class anti-anginal drug ranolazine in its racemic (RS) and enantiopure [(R) and (S)] forms …

Superoxide anion is produced during normal cellular respiration and plays key roles in
cellular physiology with its dysregulation being associated with a variety of diseases …

Protocatechuic acid (PA), a structurally typical phenolic acid in danshen, shows anti-angina
efficacy. But until now, besides scavenging of oxygen free radicals, the understanding of its …

Ischemia reperfusion injury contributes to adverse cardiovascular diseases in part by
producing a burst of reactive oxygen species that induce oxidations of many muscular …

Diastolic dysfunction can lead to heart failure with preserved ejection fraction, for which
there is no effective therapeutic. Ranolazine has been reported to reduce diastolic …