Quantitative proteomics characterization of cancer biomarkers and treatment

XL Yang, Y Shi, DD Zhang, R Xin, J Deng… - Molecular Therapy …, 2021 - cell.com
Cancer accounted for 16% of all death worldwide in 2018. Significant progress has been
made in understanding tumor occurrence, progression, diagnosis, treatment, and prognosis …

Targeting growth factor signaling pathways in pancreatic cancer: towards inhibiting chemoresistance

N Xelwa, GP Candy, J Devar… - Frontiers in …, 2021 - frontiersin.org
Pancreatic cancer is one of the most deadly cancers, ranking amongst the top leading cause
of cancer related deaths in developed countries. Features such as dense stroma …

[HTML][HTML] Urine-HILIC: Automated sample preparation for bottom-up urinary proteome profiling in clinical proteomics

IS Govender, R Mokoena, S Stoychev, P Naicker - Proteomes, 2023 - mdpi.com
Proteomes | Free Full-Text | Urine-HILIC: Automated Sample Preparation for Bottom-Up Urinary
Proteome Profiling in Clinical Proteomics Next Article in Journal Comparative Proteomic …

Proteomic analysis identifies dysregulated proteins and associated molecular pathways in a cohort of gallbladder cancer patients of African ancestry

P Baichan, P Naicker, TN Augustine, M Smith… - Clinical Proteomics, 2023 - Springer
Background Gallbladder cancer (GBC) is a lethal cancer with a poor prognosis. The lack of
specific and sensitive biomarkers results in delayed diagnosis with most patients presenting …

Proteomic insights into the pathophysiology of hypertension-associated albuminuria: Pilot study in a South African cohort

MA Govender, SH Stoychev, JT Brandenburg… - Clinical Proteomics, 2024 - Springer
Background Hypertension is an important public health priority with a high prevalence in
Africa. It is also an independent risk factor for kidney outcomes. We aimed to identify …

Comparative Proteomic Analysis of Huh7 Cells Transfected with Sub-Saharan African Hepatitis B Virus (Sub) genotypes Reveals Potential Oncogenic Factors

K Padarath, A Deroubaix, P Naicker, S Stoychev… - Viruses, 2024 - mdpi.com
In sub-Saharan Africa (SSA), the (sub) genotypes A1, D3, and E of the hepatitis B virus
(HBV) prevail. Individuals infected with subgenotype A1 have a 4.5-fold increased risk of …

Protein tyrosine kinase 7‑knockdown inhibits oral squamous cell carcinoma cell viability, proliferation, migration and invasion via downregulating dishevelled segment …

X Jin, T Huang, C Ma, J Duan, R Li… - Experimental and …, 2021 - spandidos-publications.com
Abstract Protein tyrosine kinase 7 (PTK7) expression has been reported to be dysregulated
and to regulate various cellular activities in numerous types of cancer. However, to the best …

Comparison of the Proteome of Huh7 Cells Transfected with Hepatitis B Virus Subgenotype A1, with or without G1862T

K Padarath, A Deroubaix, P Naicker… - Current Issues in …, 2024 - pmc.ncbi.nlm.nih.gov
HBeAg is a non-structural, secreted protein of hepatitis B virus (HBV). Its p25 precursor is
post-translationally modified in the endoplasmic reticulum. The G1862T precore mutation …

[PDF][PDF] Inhibition of the Complement Pathway Induces Cellular Proliferation and Migration in Pancreatic Ductal Adenocarcinoma

Z Nsingwane, P Naicker… - JOURNAL OF …, 2024 - researchgate.net
Background: Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a growing
incidence and mortality despite novel therapeutic strategies. Its aggressiveness and difficulty …

Inhibition of the Complement Pathway Induces Cellular Proliferation and Migration in Pancreatic Ductal Adenocarcinoma

Z Nsingwane, P Naicker, J Omoshoro-Jones, J Devar… - medRxiv, 2023 - medrxiv.org
Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a growing incidence and
mortality despite novel therapeutic strategies. The complement signalling pathway may play …