The role of neuroinflammation in postoperative cognitive dysfunction: moving from hypothesis to treatment

SA Safavynia, PA Goldstein - Frontiers in psychiatry, 2019 - frontiersin.org
Postoperative cognitive dysfunction (POCD) is a common complication of the surgical
experience and is common in the elderly and patients with preexisting neurocognitive …

Sleep, pain, and cognition: modifiable targets for optimal perioperative brain health

BP O'Gara, L Gao, ER Marcantonio… - …, 2021 - pmc.ncbi.nlm.nih.gov
Multicomponent interventions are effective in preventing postoperative delirium, and work is
ongoing to determine if they can be effective in preventing other postoperative …

American society for enhanced recovery and perioperative quality initiative joint consensus statement on postoperative delirium prevention

CG Hughes, CS Boncyk, DJ Culley… - Anesthesia & …, 2020 - journals.lww.com
Postoperative delirium is a geriatric syndrome that manifests as changes in cognition,
attention, and levels of consciousness after surgery. It occurs in up to 50% of patients after …

[HTML][HTML] Guidelines for perioperative care for emergency laparotomy Enhanced Recovery After Surgery (ERAS) Society recommendations: part 1—preoperative …

CJ Peden, G Aggarwal, RJ Aitken, ID Anderson… - World journal of …, 2021 - Springer
Background Enhanced Recovery After Surgery (ERAS) protocols reduce length of stay,
complications and costs for a large number of elective surgical procedures. A similar …

Effect of cognitive prehabilitation on the incidence of postoperative delirium among older adults undergoing major noncardiac surgery: the neurobics randomized …

ML Humeidan, JPC Reyes, A Mavarez-Martinez… - JAMA …, 2021 - jamanetwork.com
Importance Postoperative delirium in older adults is a common and costly complication after
surgery. Cognitive reserve affects the risk of postoperative delirium, and thus preoperative …

Brief preoperative screening for frailty and cognitive impairment predicts delirium following spine surgery

MJ Susano, RH Grasfield, M Friese, B Rosner… - …, 2020 - pmc.ncbi.nlm.nih.gov
Background: Frailty and cognitive impairment are associated with postoperative delirium but
are rarely assessed preoperatively. The study was designed to test the hypothesis that …

Best practices for postoperative brain health: recommendations from the fifth international perioperative neurotoxicity working group

M Berger, KJ Schenning, CH Brown IV… - Anesthesia & …, 2018 - journals.lww.com
As part of the American Society of Anesthesiology Brain Health Initiative goal of improving
perioperative brain health for older patients, over 30 experts met at the fifth International …

Consensus Guidelines for Perioperative Care for Emergency Laparotomy Enhanced Recovery After Surgery (ERAS®) Society Recommendations Part 2—Emergency …

MJ Scott, G Aggarwal, RJ Aitken, ID Anderson… - World journal of …, 2023 - Springer
Abstract Background This is Part 2 of the first consensus guidelines for optimal care of
patients undergoing emergency laparotomy (EL) using an Enhanced Recovery After …

Postoperative outcomes in older surgical patients with preoperative cognitive impairment: A systematic review and meta-analysis

L Chen, E Au, A Saripella, P Kapoor, E Yan… - Journal of Clinical …, 2022 - Elsevier
Study objective To determine the effect of cognitive impairment (CI) and dementia on
adverse outcomes in older surgical patients. Design A systematic review and meta-analysis …

Electroencephalogram burst-suppression during cardiopulmonary bypass in elderly patients mediates postoperative delirium

JC Pedemonte, GS Plummer, S Chamadia… - …, 2020 - pmc.ncbi.nlm.nih.gov
Background: Intraoperative burst-suppression is associated with postoperative delirium.
Whether this association is causal remains unclear. Therefore, we investigated whether …