The inhibitor of apoptosis protein survivin's threonine 34 to alanine (T34A) mutation
abolishes a phosphorylation site for p34 (cdc2)–cyclin B1, resulting in initiation of the …

Excess acetate has long been an issue for the production of recombinant proteins in E. coli
cells. Recently, improvements in acetate tolerance have been achieved through the use of …

Regulation of the apoptotic pathway plays a critical role in inducing tumor cell death and
circumventing drug resistance. Survivin protein is the strongest inhibitor of apoptosis found …

Survivin is a well-known inhibitor-of-apoptosis proteins family member and a promising
molecular target for anti-cancer treatment. However, it is widely accepted that survivin is only …

Survivin as a member of the inhibitor of apoptosis proteins (IAPs) family is undetectable in
normal cells, but highly expressed in cancer cells and cancer stem cells (CSCs) which …

Therapeutic recombinant proteins have numerous advantages and benefits over chemical
drugs, particularly high specificity and good biocompatibility. However, the therapeutic …

In order to develop an effective strategy of breast cancer therapy targeting survivin and its
splice variants survivin-ΔEx3 and survivin-2B, the present study constructed four expression …

A fed-batch process was developed for intracellular production of recombinant TATm-
survivin (T34A) in Escherichia coli under the control of T7 promoter. The effects of induction …

Survivin is an important protein in regulating both cell apoptosis and proliferation. It has
attracted growing attentions in recent years as a promising target for cancer therapy …

ABSTRACT Human interleukin 2 protein (IL-2) is an important cytokine found to be elevated
in several types of cancer. A synthetic DNA sequence of the cDNA of mature IL-2 protein …