Heart failure with preserved ejection fraction (HFpEF) involves multiple pathophysiological
mechanisms, which result in the heterogeneous phenotypes that are evident clinically, and …

Normal cardiac function requires that intracellular Ca2+ concentration be reduced to low
levels in diastole so that the ventricle can relax and refill with blood. Heart failure is often …

Heart Failure (HF) is defined as the inability of the heart to efficiently pump out enough blood
to maintain the body's needs, first at exercise and then also at rest. Alterations in Ca2+ …

Fetuin-A, also termed alpha2-Heremans-Schmid glycoprotein, is a 46 kDa hepatocyte
derived protein (hepatokine) and serves multifaceted functions.(i) It acts as systemic inhibitor …

The goal of this paper was to provide a real-time left ventricular (LV) mechanics simulator
using machine learning (ML). Finite element (FE) simulations were conducted for the LV with …

Heart failure with preserved ejection fraction (HFpEF) is a multifaceted syndrome with a
complex aetiology often associated with several comorbidities, such as left ventricle …

Ferroptosis is a recently identified cell death characterized by an excessive accumulation of
iron-dependent reactive oxygen species (ROS) and lipid peroxides. Intracellular iron …

The current classification of heart failure (HF) based on left ventricular (LV) ejection fraction
(EF) identifies a large group of patients with preserved ejection fraction (HFpEF) with …

Aims Patients with heart failure with preserved ejection fraction (HFpEF) are characterized
by impaired diastolic function. Left ventricular (LV) strain–volume loops (SVL) represent the …

Heart failure with preserved ejection fraction (HFpEF) is a common clinical syndrome
associated with high morbidity and mortality. Therapeutic options are limited due to a lack of …