Accumulating evidence suggests that a high tumour burden has a negative effect on
anticancer immunity. The concept of tumour burden, simply defined as the total amount of …

Peripheral blood inflammatory indices, like the neutrophil-to-lymphocyte ratio (NLR), may
reflect the host's pro-inflammatory status and systemic immune response to cancer-related …

Purpose: Emerging evidence indicates that gut microbiota dysbiosis can reduce the
effectiveness of immune checkpoint inhibitors (ICI). Proton pump inhibitors (PPI) are known …

Background: Bone metastases and skeletal-related events (SREs) are a frequent cause of
morbidity in patients with metastatic non–small cell lung cancer (mNSCLC). Data are limited …

Immune checkpoint inhibitors (ICI) have revolutionized the treatment landscape of several
solid tumor types. However, as patient outcomes are heterogeneous, clinical tools to aid in …

Background: Lung neuroendocrine carcinoma (NEC) is characterized by aggressive clinical
behavior and lack of treatment advances. We evaluate the prognostic and the predictive …

Background dNLR at the baseline (B), defined by neutrophils/[leucocytes-neutrophils],
correlates with immune-checkpoint inhibitor (ICI) outcomes in advanced non–small-cell lung …

Purpose of review To describe the biological rationale of peripheral blood cells (PBC)–
derived inflammatory indexes and assess the related prognostic scores for patients with …

Simple Summary Immune checkpoint inhibitors (ICI) are now a cornerstone of treatment for
non-small cell lung cancer (NSCLC). Despite reporting tremendous results for some …

The emergence of immunotherapy, particularly programmed cell death 1 (PD-1) and
programmed cell death ligand-1 (PD-L1) produced profound transformations for treating non …