The PI3K/PKB signaling module as key regulator of hematopoiesis: implications for therapeutic strategies in leukemia
R Polak, M Buitenhuis - Blood, The Journal of the American …, 2012 - ashpublications.org
An important mediator of cytokine signaling implicated in regulation of hematopoiesis is the
PI3K/protein kinase B (PKB/c-Akt) signaling module. Constitutive activation of this signaling …
PI3K/protein kinase B (PKB/c-Akt) signaling module. Constitutive activation of this signaling …
Zebrafish as a model for leukemia and other hematopoietic disorders
P Rasighaemi, F Basheer, C Liongue… - Journal of hematology & …, 2015 - Springer
Zebrafish is an established model for the study of vertebrate development, and is especially
amenable for investigating hematopoiesis, where there is strong conservation of key …
amenable for investigating hematopoiesis, where there is strong conservation of key …
[PDF][PDF] Hepatic transforming growth factor beta gives rise to tumor‐initiating cells and promotes liver cancer development
K Wu, J Ding, C Chen, W Sun, BF Ning, W Wen… - …, 2012 - Wiley Online Library
Liver cirrhosis is a predominant risk factor for hepatocellular carcinoma (HCC). However, the
mechanism underlying the progression from cirrhosis to HCC remains unclear. Herein we …
mechanism underlying the progression from cirrhosis to HCC remains unclear. Herein we …
Epigenetic silencing of microRNA-193a contributes to leukemogenesis in t(8;21) acute myeloid leukemia by activating the PTEN/PI3K signal pathway
Abstract t (8; 21) is one of the most frequent chromosomal translocations occurring in acute
myeloid leukemia (AML) and is considered the leukemia-initiating event. The biologic and …
myeloid leukemia (AML) and is considered the leukemia-initiating event. The biologic and …
JMJD3 facilitates C/EBPβ-centered transcriptional program to exert oncorepressor activity in AML
SH Yu, KY Zhu, J Chen, XZ Liu, PF Xu, W Zhang… - Nature …, 2018 - nature.com
JMJD3, a stress-inducible H3K27 demethylase, plays a critical regulatory role in the
initiation and progression of malignant hematopoiesis. However, how this histone modifier …
initiation and progression of malignant hematopoiesis. However, how this histone modifier …
New functions for alpha-catenins in health and disease: from cancer to heart regeneration
Strong cell–cell adhesion mediated by adherens junctions is dependent on anchoring the
transmembrane cadherin molecule to the underlying actin cytoskeleton. To do this, the …
transmembrane cadherin molecule to the underlying actin cytoskeleton. To do this, the …
Regulation of monocyte differentiation by specific signaling modules and associated transcription factor networks
R Huber, D Pietsch, J Günther, B Welz, N Vogt… - Cellular and molecular …, 2014 - Springer
Monocyte/macrophages are important players in orchestrating the immune response as well
as connecting innate and adaptive immunity. Myelopoiesis and monopoiesis are …
as connecting innate and adaptive immunity. Myelopoiesis and monopoiesis are …
The role of PTEN in myeloid malignancies
PTEN deletion in the mouse and in the zebrafish highlights the essential role of this tumor
suppressor in the development of myeloid malignancies, in particular acute myeloid …
suppressor in the development of myeloid malignancies, in particular acute myeloid …
中国斑马鱼研究发展历程及现状
贾顺姬， 孟安明 - 遗传, 2012 - chinagene.cn
斑马鱼作为重要的脊椎动物模式系统之一, 由于其多方面的优势, 在生命科学研究领域发挥着越
来越重要的作用. 目前, 斑马鱼已被广泛地用于发育生物学, 分子生物学, 细胞生物学, 遗传学 …
来越重要的作用. 目前, 斑马鱼已被广泛地用于发育生物学, 分子生物学, 细胞生物学, 遗传学 …
Pharmacologic co-inhibition of Mnks and mTORC1 synergistically suppresses proliferation and perturbs cell cycle progression in blast crisis-chronic myeloid leukemia …
Abstract The Ras/Raf/MAPK and PI3K/Akt/mTORC1 cascades are two most aberrantly
regulated pathways in cancers. As MAPK-interacting kinases (Mnks) are part of the …
regulated pathways in cancers. As MAPK-interacting kinases (Mnks) are part of the …