Childhood trauma in schizophrenia: current findings and research perspectives
Schizophrenia is a severe neuropsychiatric disorder with persistence of symptoms
throughout adult life in most of the affected patients. This unfavorable course is associated …
throughout adult life in most of the affected patients. This unfavorable course is associated …
Schizophrenia and the environment: within-person analyses may be required to yield evidence of unconfounded and causal association—the example of cannabis …
Hypotheses about the link between cannabis use and psychosis apply to the within-person
level but have been tested mostly at the between-person level. We used a within-person …
level but have been tested mostly at the between-person level. We used a within-person …
Examining the independent and joint effects of molecular genetic liability and environmental exposures in schizophrenia: results from the EUGEI study
Schizophrenia is a heritable complex phenotype associated with a background risk
involving multiple common genetic variants of small effect and a multitude of environmental …
involving multiple common genetic variants of small effect and a multitude of environmental …
Association of preceding psychosis risk states and non‐psychotic mental disorders with incidence of clinical psychosis in the general population: A prospective study …
The validity and clinical utility of the concept of “clinical high risk”(CHR) for psychosis have
so far been investigated only in risk‐enriched samples in clinical settings. In this population …
so far been investigated only in risk‐enriched samples in clinical settings. In this population …
Examining the independent and joint effects of genomic and exposomic liabilities for schizophrenia across the psychosis spectrum
AimsPsychosis spectrum disorder has a complex pathoetiology characterised by interacting
environmental and genetic vulnerabilities. The present study aims to investigate the role of …
environmental and genetic vulnerabilities. The present study aims to investigate the role of …
Association of recent stressful life events with mental and physical health in the context of genomic and exposomic liability for schizophrenia
Importance Both adulthood stressful life events (SLEs) and liability for schizophrenia have
been associated with poor mental and physical health in the general population, but their …
been associated with poor mental and physical health in the general population, but their …
Heritability of psychotic experiences in adolescents and interaction with environmental risk
Importance Genetic risk factors are known to play a role in the etiology of psychotic
experiences in the general population. Little is known about whether these risk factors …
experiences in the general population. Little is known about whether these risk factors …
Polygenic liability for schizophrenia and childhood adversity influences daily‐life emotion dysregulation and psychosis proneness
LK Pries, B Klingenberg… - Acta Psychiatrica …, 2020 - Wiley Online Library
Objective To test whether polygenic risk score for schizophrenia (PRS‐S) interacts with
childhood adversity and daily‐life stressors to influence momentary mental state domains …
childhood adversity and daily‐life stressors to influence momentary mental state domains …
Do current measures of polygenic risk for mental disorders contribute to population variance in mental health?
A Marsman, LK Pries, M Ten Have… - Schizophrenia …, 2020 - academic.oup.com
The polygenic risk score (PRS) allows for quantification of the relative contributions of genes
and environment in population-based studies of mental health. We analyzed the impact of …
and environment in population-based studies of mental health. We analyzed the impact of …
Childhood maltreatment mediates the effect of the genetic background on psychosis risk in young adults
Childhood maltreatment (CM) and genetic vulnerability are both risk factors for psychosis,
but the relations between them are not fully understood. Guided by the recent identification …
but the relations between them are not fully understood. Guided by the recent identification …