Lipids, phospholipids and cholesterol in particular, are the predominant components of the plasma membrane, wherein multidrug efflux transporters of the ATP-binding cassette (ABC) …
J Dong, Z Qin, WD Zhang, G Cheng, AG Yehuda… - Drug Resistance …, 2020 - Elsevier
The presence of multidrug resistance (MDR) in malignant tumors is one of the primary causes of treatment failure in cancer chemotherapy. The overexpression of the ATP binding …
ML Amin - Drug target insights, 2013 - journals.sagepub.com
P-glycoprotein (P-gp), an efflux membrane transporter, is widely distributed throughout the body and is responsible for limiting cellular uptake and the distribution of xenobiotics and …
Abstract P-glycoprotein (P-gp) is an ATP-dependent efflux pump encoded by the MDR1 gene in humans, known to mediate multidrug resistance of neoplastic cells to cancer …
Drug efflux pumps like P-glycoprotein (P-gp) and multidrug resistance (MDR) proteins were recognized to posses functional role in determining the pharmacokinetics of drugs …
FJ Sharom - The Journal of membrane biology, 1997 - researchgate.net
The development of multidrug resistance (MDR) is a major obstacle in the chemotherapeutic treatment of many human cancers, including colon, kidney and breast carcinomas …
The development of drug resistance continues to be a dominant hindrance toward curative cancer treatment. Overexpression of a wide-spectrum of ATP-dependent efflux pumps, and …
S Zhang, ME Morris - Journal of Pharmacology and Experimental …, 2003 - ASPET
Flavonoids are constituents of fruits, vegetables, and plant-derived beverages, as well as components in herbal-containing dietary supplements. The objective of this investigation …
We have recently shown that hydrophobic weak base anticancer drugs are highly sequestered in acidic lysosomes, inducing TFEB-mediated lysosomal biogenesis and …