Liver sinusoidal endothelial cells—gatekeepers of hepatic immunity
Liver sinusoidal endothelial cells (LSECs) line the low shear, sinusoidal capillary channels
of the liver and are the most abundant non-parenchymal hepatic cell population. LSECs do …
of the liver and are the most abundant non-parenchymal hepatic cell population. LSECs do …
Liver fibrosis and repair: immune regulation of wound healing in a solid organ
A Pellicoro, P Ramachandran, JP Iredale… - Nature Reviews …, 2014 - nature.com
Fibrosis is a highly conserved and co-ordinated protective response to tissue injury. The
interaction of multiple pathways, molecules and systems determines whether fibrosis is self …
interaction of multiple pathways, molecules and systems determines whether fibrosis is self …
AASLD practice guidance on primary sclerosing cholangitis and cholangiocarcinoma
Abbreviations: AASLD, American Association for the Study of Liver Diseases; AIH,
autoimmune hepatitis; ALP, alkaline phosphatase; ASIR, age standardized incidence rate; …
autoimmune hepatitis; ALP, alkaline phosphatase; ASIR, age standardized incidence rate; …
[PDF][PDF] The ascending pathophysiology of cholestatic liver disease
In this review we develop the argument that cholestatic liver diseases, particularly primary
biliary cholangitis and primary sclerosing cholangitis (PSC), evolve over time with …
biliary cholangitis and primary sclerosing cholangitis (PSC), evolve over time with …
Primary sclerosing cholangitis
GM Hirschfield, TH Karlsen, KD Lindor, DH Adams - The Lancet, 2013 - thelancet.com
Primary sclerosing cholangitis is the classic hepatobiliary manifestation of inflammatory
bowel disease and is generally chronic and progressive. Patients frequently present with …
bowel disease and is generally chronic and progressive. Patients frequently present with …
Leukocyte trafficking to the small intestine and colon
A Habtezion, LP Nguyen, H Hadeiba, EC Butcher - Gastroenterology, 2016 - Elsevier
Leukocyte trafficking to the small and large intestines is tightly controlled to maintain
intestinal immune homeostasis, mediate immune responses, and regulate inflammation. A …
intestinal immune homeostasis, mediate immune responses, and regulate inflammation. A …
[HTML][HTML] Inflammatory bowel disease and primary sclerosing cholangitis: one disease or two?
KN van Munster, A Bergquist, CY Ponsioen - Journal of Hepatology, 2024 - Elsevier
Primary sclerosing cholangitis (PSC) was declared one of the biggest unmet needs in
hepatology during International Liver Congress 2016 in Berlin. Since then, not much has …
hepatology during International Liver Congress 2016 in Berlin. Since then, not much has …
Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management
Primary sclerosing cholangitis (PSC), first described in the mid-1850s, is a complex liver
disease that is heterogeneous in its presentation. PSC is characterized by chronic …
disease that is heterogeneous in its presentation. PSC is characterized by chronic …
The role of sinusoidal endothelial cells in the axis of inflammation and cancer within the liver
AL Wilkinson, M Qurashi, S Shetty - Frontiers in physiology, 2020 - frontiersin.org
Liver sinusoidal endothelial cells (LSEC) form a unique barrier between the liver sinusoids
and the underlying parenchyma, and thus play a crucial role in maintaining metabolic and …
and the underlying parenchyma, and thus play a crucial role in maintaining metabolic and …
Innate immune cells in liver inflammation
Innate immune system is the first line of defence against invading pathogens that is critical
for the overall survival of the host. Human liver is characterised by a dual blood supply, with …
for the overall survival of the host. Human liver is characterised by a dual blood supply, with …