Large numbers of inhibitors for polo-like kinases and aurora kinases are currently being
evaluated as anticancer drugs. Interest in these drugs is fuelled by the idea that these …

Neuroblastoma is the most common extracranial solid tumor of children. Neuroblastoma
tumors derive from the neural crest and synthesize neurotransmitters including the …

In pugilistic parlance, the one-two punch is a devastating combination of blows, with the first
punch setting the stage and the second delivering the knock-out. This analogy can be …

Increased Aurora A expression occurs in a variety of human cancers and induces
chromosomal abnormalities during mitosis associated with tumor initiation and progression …

The human aurora family of serine-threonine kinases comprises three members, which act
in concert with many other proteins to control chromosome assembly and segregation …

Objective: This study aimed to identify the oncogenes at 20q involved in colorectal adenoma
to carcinoma progression by measuring the effect of 20q gain on mRNA expression of genes …

The Aurora kinase family is a collection of highly related serine/threonine kinases that
functions as a key regulator of mitosis. In mammalian cells, Aurora has evolved into three …

HOTTIP is a long non-coding RNA (lncRNA) transcribed from the 5′ tip of the HOXA locus
and is associated with the polycomb repressor complex 2 (PRC2) and WD repeat containing …

Most gene expression profiling studies of mesothelioma have been based on relatively
small sample numbers, limiting their statistical power. We did Affymetrix U133A microarray …

Drugs that interfere with the normal progression of mitosis belong to the most successful
chemotherapeutic compounds currently used for anti-cancer treatment. Classically, these …